口腔鳞状细胞癌中Slug及E-cadherin的表达

Abstract

Abstract: Objective　 To investigate the expressions and the differences of Slug and E-cadherin in oral squamous cell carcinoma（OSCC）. Methods: The mRNA levels of Slug and E-cadherin in 30 cases of OSCC tissues and 20 cases of oral mucosa tissues were detected by rt-PCR, then the relationship between the expression and pathological features was analyzed. Results: The expression of Slug in OSCC tissues was higher than in oral mucosa tissues （P<0.05）while the expression of E-cadherin in OSCC tissues was lower than in oral mucosa tissues （P<0.05）.The expressions of Slug and E-cadherin had correlation with TNM stage and lymph node metastasis（P<0.05）, but not with gender, age, cell differentiation degree and deeper invasion（P＞0.05）. Conclusion: The expressions of Slug and E-cadherin in OSCC are closely related to the development , invasion and metastasis of the tumor.

Key words: Slug, E-cadherin, EMT, oral squamous cell carcinoma

CLC Number:

R739.85

References

[1]Argiris A,Karamouzis M V.Raben Det al. Head and neck cancer[J].. The Lancet,9625,2008:371-
[2]Hirshberg A,Shnaiderman-Shapiro A,Kaplan I,et al.Metastatic tumours to the oral cavity–Pathogenesis and analysis of 673 cases[J].Oral Oncology,2008,44(8):743-752
[3] Masthan K M K,Babu N A,Dash K C,et al.Asian Pac J Cancer Prev,2012,13(8):3573-3576
[4]Moon Y,Kim D,Sohn H,et al.Effect of CD133 overexpression on the epithelial-to-mesenchymal transition in oral cancer cell lines[J].Clin Exp Metastasis,2016,33(5):487-496
[5]刘锦华，唐旭东.Slug的分子调控机制[J].生命的化学,2013,33(05):554-562
[6]Beavon I R.The E-cadherin-catenin complex in tumour metastasis: structure,function and regulation[J].Eur J Cancer,2000,36(13 Spec No):1607-1620
[7]Palma C S,Grassi M L,Thome C H,et al.Proteomic Analysis of Epithelial to Mesenchymal Transition (EMT) Reveals Cross-talk between SNAIL and HDAC1 Proteins in Breast Cancer Cells[J].Mol Cell Proteomics,2016,15(3):906-917
[8]Zheng M,Jiang Y P,Chen W,et al.Snail and Slug collaborate on EMT and tumor metastasis through miR-101-mediated EZH2 axis in oral tongue squamous cell carcinoma[J].Oncotarget,2015,6(9):6797-6810
[9]Yang H W,Menon L G,Black P M,et al.SNAI2/Slug promotes growth and invasion in human gliomas[J].BMC Cancer,2010,301(10):1471-2407
[10]Jiang Y,Zhao X,Xiao Q,et al.Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition[J].J Mol Cell Biol,2014,6(4):352-354
[11]Rajabpour F V,Raoofian R,Youssefian L,et al.BMI1 and TWIST1 downregulated mRNA expression in basal cell carcinoma[J].Asian Pac J Cancer Prev,2014,15(8):3797-3800
[12]Wang W,Yi M,Chen S,et al.Significance of the NOR1-FOXA1/HDAC2-Slug regulatory network in epithelial-mesenchymal transition of tumor cells[J].. Oncotarget,2016,7(13):16745-16759
[13]Da Silva SD,Morand GB,Alobaid FA,et al.Epithelial-mesenchymal transition (EMT) markers have prognostic impact in multiple primary oral squamous cell carcinoma[J].Clin Exp Metastasis,2015,32(1):55-63
[14]Alves C C,Rosivatz E,Schott C,et al.Slug is overexpressed in gastric carcinomas and may act synergistically with SIP1 and Snail in the down-regulation of E-cadherin[J].J Pathol,2007,211(5):507-515
[15]Qian J,Liu H,Chen W,et al.Knockdown of Slug by RNAi inhibits the proliferation and invasion of HCT116 colorectal cancer cells[J].. Molecular Medicine Reports,2013,8(4):1055-1059
[16]Kumar A,Chatopadhyay T,Raziuddin M,et al.Discovery of deregulation of zinc homeostasis and its associated genes in esophageal squamous cell carcinoma using cDNA microarray[J].Int J Cancer,2007,120(2):230-242
[17]Kojc N,Zidar N,Gale N,et al.Transcription factors Snail,Slug,Twist,and SIP1 in spindle cell carcinoma of the head and neck[J].Virchows Archiv,2009,454(5):549-555
[18]Luanpitpong S,Li J,Manke A,et al.SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma[J].. Oncogene,2015,35(22):2824-2833
[19]郑彩云，汪鹏，沈显军，等.E-cadherin和Slug在口腔鳞状细胞癌中的表达及临床意义[J].医学研究杂志,2016,45(05):1673-548

The expressions of Slug and E-cadherin in oral squamous cell carcinoma

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