Abstract: Localized and continuous osteogenic stimulation to defected site is required for effective bone regeneration. Growth factors are very promising molecules to enhance bone regeneration and enable the recruitment of enough endogenous functional cells to the defect regions and promotion of their committed differentiation at appropriate times to reestablish the destroyed tissues. However, the application of the growth factors to clinical practice has been seriously confined, and the problems derived from the determination of the optimal dose of growth factors and the lack of effective delivery systems. Therefore, new delivery systems allowing better control of the spatiotemporal release need to be developed. At present, the growth factor delivery system includes the following four types: sequential delivery using a collagen membrane, injectable polymeric hydrogel and derivative structures, separate and joint application of different kinds of nanoparticles and the composite system of scaffolds. Different delivery systems have their unique characteristics, degradation and release kinetics, and they can be flexibly combined and adjusted according to the clinical needs.

Key words: tissue engineering, tissue reestablish, delivery systems, growth factors