›› 2017, Vol. 37 ›› Issue (4): 302-306.

• Basic Research • Previous Articles     Next Articles

Experimental study of repair of bone defect around implant with PRP and PRP/OAM

  

  • Received:2016-09-01 Revised:2016-10-15 Online:2017-04-28 Published:2017-04-11

Abstract: Objective To investigate the effect of rich platelet plasma (PRP) and PRP composite osteoinduction active material (PRP/OAM) on the repair of bone defect around implant. Methods Four adult Beagle dogs were selected which weight 10 ~ 13 kg, and each dogs left and right mandibular fourth molar teeth were randomly divided into group A and group B, the first and second molar teeth in the same side with group B as control group. In group A, bone defect around the implant was implanted with PRP/OAM, group B was implanted with PRP/ calcium phosphate, and the control group was implanted with calcium phosphate. The contents of Ca2+ on the implant bone interface of each group were analyzed by energy spectrum, and the histological patterns of 8 and 16 weeks after implantation were observed. Results Ca2+ content on the planting body bone surface of group A and group B planting after 8 and 16 weeks was significantly higher than that of the control group (P<0.05); Ca2+ content on the planting body bone surface of group A planting after 8, 16 weeks were (26.01±3.28)% and (44.10±7.11)%, which were significantly higher than that in group B (P<0.05); 8 weeks after implantation, in group A new bone and implant formed sectional osseointegration, in group B new bone formed at the implant edge, and the control group implant edge was fibrous interface; 16 weeks after implantation, in group A and group B new bone and implant formed bone integration, in the control group it was only fibrous combination. Conclusion PRP and PRP/OAM in the repair of bone defects around implants can effectively promote the repair of bone defects.

Key words: dental implant, bone defect, rich platelet plasma, osteoinduction active material, dog

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