Abstract: Male patient, 51 years old. Double side to tooth lip side gum has burst 2 months, add 1 week. The pathological diagnosis of pemphigoid. DIF showed true epidermal junction the IgA banded deposition, IgG, C3, IgM negative. Diagnosed as linear IgA bullous skin disease, given glucocorticoid and thalidomide combination therapy, and achieved good results.

Key words: Key words: oral mucosa, Linear the lgA bullous skin disease, immunofluorescence