Abstract: During biomineralization of hard tissues, minerals deposit on the collagen , then form mineralized collagen with the induction of biological macromolecules proteins, polysaccharides and so on. Collagen has a very important role in different stages of biomineralization. Types and levels of bone and dentin mineralization affect the quality and quantity of its corresponding function in vivo. Therefore, restoration of hierarchical structures of the mineralized collagen matrix and a thorough understanding of the underlying role of type 1 collagen can provide useful reference for preparing new bone and dentin repair material and tissue-engineered substitutes .This review discusses the research progress of the role of type 1 collagen in biomineralization .

Key words: Type 1 Collagen, Collagen fiber , Biomineralization, Intrafibrillar mineralization