›› 2017, Vol. 37 ›› Issue (9): 800-804.

• Basic Research • Previous Articles     Next Articles

The role of TREK-1 in orofacial pain induced by experimental tooth movement in rats

  

  • Received:2017-03-31 Revised:2017-05-31 Online:2017-09-28 Published:2017-09-22

Abstract: Objective To establish a craniofacial pain model induced by tooth movement in rats, and to elucidate the role of potassium channel TREK1 in mediating craniofacial pain. Methods Eighty female SpragueDawley rats were randomly divided into four groups: the experimental group, the control group, Fluoxetine treated group and Quinidine treated group . The distance of the tooth movement was measured by the Xray films;the degree of pain was evaluated using the RGS index, and the expression of TREK1 in the periodontal tissue was observed by immunohistochemical staining. Results The mesial movement of the first molar in the experimental group increased over time and reached the maximum amount on 14th day. The pain score of the rats in the experiment group was higher than that of control group and the most obvious pain occurred on 3rd day ;on 3rd day, TREK1 highly expressed in the periodontal vascular wall; Fluoxetine and Quinidine (chemical inhibitors of TREK1) reduced the pain caused by tooth movement, and did not affect the speed and distance of tooth movement. Conclusion TREK1 mediates the development of craniofacial pain during tooth movement in rats. TREK1 can relieve the maxillofacial pain caused by tooth movement without affecting the efficiency of tooth movement.

Key words: TREK-1, experimental tooth movement, orofacial pain

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