RAGE基因多态性与2型糖尿病伴慢性牙周炎遗传易感性的相关研究

Abstract

Abstract: [Abstract] Objective: To investigate the differential distributions of five single nucleotide polymorphism (SNP) loci of RAGE gene in type 2 diabetes with chronic periodontitis (DM), chronic periodontitis (CP), and healthy controls among northern Chinese Han people, so as to study whether RAGE gene serves as a susceptible candidate gene for both diabetes and periodontitis. Methods: Utilized a flight-time mass spectrometer method to analyze five SNPs of 19 DM subjects, 22 CP subjects, and 54 healthy subjects. Results: The distributions of rs17846808, rs1800625, rs184003, rs2070600, rs3134940 polymorphisms demonstrated no significance among three groups. In DM group, subjects carrying rs3134940 A/A genotype had higher SBI than those carrying A/G+G/G genotypes. In CP group, subjects carrying rs1800625 (T/C+C/C) and rs3134940 (A/G+G/G) genotypes had significant higher loss of teeth. Conclusion: In the samples of this study, RAGE gene fails to demonstrate its potential to be a candidate gene for type 2 diabetes and chronic periodontitis susceptibilities. rs3134940 G allele may have some protective roles in the progression of type 2 diabetes with chronic periodontitis. On top of that, larger studies need to be included to draw any further conclusions.

Key words: gene polymorphisms, type2 diabetes mellitus, chronic periodontitis, RAGE

CLC Number:

R780.2

References

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A study on the association between RAGE gene polymorphisms and type2 diabetes mellitus with chronic periodontitis.

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