B细胞在牙周炎免疫进程中的作用机制研究

Abstract

Abstract: Previous research showed that B cell mediated humoral immunity play a major role in the process of periodontitis. The antibody producted by B cells, in this process, not only neutralize antigen but also destroy host tissues because of antigen cross, molecular mimicry or epitope spreading. In addition, B cells secretes cytokines to regulate immune process, active osteoclast then lead to imbalance of bone formation and resorption. Furthermore, autoimmunity related to B cell also has something to do with periodontits. As a result, exploring B cells’ function and influence became the key of understanding periodontitis.

Key words: periodontits, B cells, Immune process

CLC Number:

R781.4

Ya-Kun HAN. B cells in periodontitis immune process??：roles and effects[J]. , 2018, 38(1): 66-72.

References

[1]Kassebaum,NJ,E Bernabe,M Dahiya,et al.Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression[J].J Dent Res,2014,93 (11):1045-1053 [2]Choi SC,Morel L.B cell contribution of the CD4+ T cell inflammatory phenotypes in systemic lupus erythematosus[J].Autoimmunity,2017,50(1):37-41 [3]Crotty S.T follicular helper cell differentiation,function,and roles in disease[J].Immunity,2014,41(4):529-542 [4]Rosser EC,Mauri C.Regulatory B cells: origin,phenotype,and function[J].Immunity,2015,42(4):607-612 [5]Zhu M,Belkina AC,DeFuria J,et al.B cells promote obesity-associated periodontitis and oral pathogen-associated inflammation[J].J Leukoc Biol,2014,96(2):349-357 [6]Kim YC,Ko Y,Hong SD,et al.Presence of Porphyromonas gingivalis and plasma cell dominance in gingival ts with periodontitis[J].Oral Dis,2010,16(4):375-381 [7]Huang C,Geng H,Boss I,et al.Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation[J].Blood,2014,123(7):1012-1020 [8]Gupta SR,Gupta R,Saran RK,et al.Plasma cell mucositis with gingival enlargement and severe periodontitis[J].J Indian Soc Periodontol,2014,18(3):379-384 [9]Gümü? P,Nizam N,Lappin DF,et al.Saliva and serum levels of B-cell activating factors and tumor necrosis factor-α in patients with periodontitis[J].J Periodontol,2014,85(2):270-280 [10]Gupta N,Gupta ND,Gupta A,et al.Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis[J].Front Med,2015,9(1):72-76 [11]Al-Azri AR,Gibson RJ,Keefe DM,et al.Matrix metalloproteinases: do they play a role in mucosal pathology of the oral cavity[J].. Oral Dis,2013,9(4):347-359 [12]Martinho FC,Teixeira FF,Cardoso FG,et al.Clinical Investigation of Matrix Metalloproteinases,T Inhibitors of Matrix Metalloproteinases,and Matrix Metalloproteinase/T Inhibitors of Matrix Metalloproteinase Complexes and Their Networks in Apical Periodontitis[J].J Endod,2016,42(7):1082-1088 [13]Thorbert-Mros S,Larsson L,Berglundh T.Cellular composition of long-standing gingivitis and periodontitis lesions[J].J Periodontal Res,2015,50(4):535-543 [14] Corfe SA,Paige CJ.The many roles of IL-7 in B cell development; mediator of survival,proliferation and differentiation[J][J].Semin Immunol,2012,24(3):198-208 [15]Gümü? P,Buduneli E,Biyiko?lu B,et al.Gingival crevicular fluid and serum levels of APRIL,BAFF and TNF-alpha in rheumatoid arthritis and osteoporosis patients with periodontal disease[J].Arch Oral Biol,2013,58(10):1302-1308 [16]Abe T,AlSarhan M,Benakanakere MR,et al.The B Cell-Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell-Dependent Bone Loss in Experimental Murine Periodontitis[J].J Immunol,2015,195(4):1427-1435 [17]Park K,Ju WC,Yeo JH,et al.Increased OPG/RANKL ratio in the conditioned medium of soybean-treated osteoblasts suppresses RANKL-induced osteoclast differentiation[J].Int J Mol Med,2014,33(1):178-184 [18]Melda Onal,Jinhu Xiong,Xinrong Chen,et al Receptor Activator of Nuclear Factor κB Ligand (RANKL) Protein Expression by B Lymphocytes Contributes to Ovariectomy-induced Bone Loss[J].J Biol Chem[J].,2012,287(34):29851-29860 [19]Perlot T,Penninger JM.Development and function of murine B cells lacking RANK[J].J Immunol,2012,188(3):1201-1205 [20]Ferrari-Lacraz S,Ferrari S.Do RANKL inhibitors (denosumab) affect inflammation and immunity[J].Osteoporos Int,2011,22(2):435-446 [21]Balli U,Aydogdu A,Dede FO,et al.Gingival Crevicular Fluid Levels of Sclerostin,Osteoprotegerin,and Receptor Activator of Nuclear Factor-κB Ligand in Periodontitis[J].J Periodontol,2015,86(12):1396-1404 [22]Han X,Kawai T,Eastcott JW,et al.Bacterial-responsive B lymphocytes induce periodontal bone resorption[J].J Immunol,2006,176(1):625-631 [23] Zouali M.The emerging roles of B cells as partners and targets in periodontitis.[J][J].Autoimmunity,2017,50(1):61-70 [24]Baker PJ,Boutaugh NR,Tiffany M,et al.B Cell IgD Deletion Prevents Alveolar Bone Loss Following Murine Oral Infection[J].Interdiscip Perspect Infect Dis,2009,2009:864359- [25]Oliver-Bell J,Butcher JP,Malcolm J,et al.Periodontitis in the absence of B cells and specific anti-bacterial antibody[J].Mol Oral Microbiol,2015,30(2):160-169 [26]Wara-aswapati N,Chayasadom A,Surarit R,et al.Induction of toll-like receptor expression by Porphyromonas gingivalis[J].J Periodontol,2013,84(7):1010-1018 [27]Ma K,Li J,Fang Y,et al.Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus[J].Int J Mol Sci,2015,16(6):13084-13105 [28]L Jashi,N Gogebashvili.Autoimmune mechanisms toward type I collagen during parodontitis[J].Georgian Med News,2014,4(229):26-28 [29]Cornaby C,Gibbons L,Mayhew V,et al.B cell epitope spreading: mechanisms and contribution to autoimmune diseases[J].Immunol Lett,2015,163(1):56-68 [30] Trela M,Nelson PN,Rylance PB.The role of molecular mimicry and other factors in the association of Human Endogenous Retroviruses and autoimmunity[J][J].APMIS,2012,124(1-2):88-104 [31]Donati M,Liljenberg B,Zitzmann NU,et al.B-1a cells and plasma cells in periodontitis lesions[J].J Periodontal Res,2009,44(5):683-688 [32]Pirim Gorgun E,Toker H,Korkmaz EM,et al.IL-6 and IL-10 gene polymorphisms in patients with aggressive periodontitis: effects on GCF,serum and clinic parameters[J].Braz Oral Res,2017,31(0):- [33]Rizzo M,Cappello F,Marfil R,et al.Heat-shock protein 60 kDa and atherogenic dyslipidemia in patients with untreated mild periodontitis: a pilot study[J].Cell Stress Chaperones,2012,17(3):399-407 [34]Choi J,Lee SY,Kim K,et al.Identification of immunoreactive epitopes of the Porphyromonas gingivalis heat shock protein in periodontitis and atherosclerosis[J].J Periodontal Res,2011,46(2):240-245 [35]Jeong E,Lee JY,Kim SJ,et al.Predominant immunoreactivity of Porphyromonas gingivalis heat shock protein in autoimmune diseases[J].J Periodontal Res,2012,47(6):811-816 [36]Lange L,Thiele GM,McCracken C,et al.Symptoms of periodontitis and antibody responses to Porphyromonas gingivalis in juvenile idiopathic arthritis[J].Pediatr Rheumatol Online J,2016,14(1):8- [37]de Pablo P,Dietrich T,Chapple IL,et al.The autoantibody repertoire in periodontitis: a role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis[J].. Ann Rheum Dis,2014,73(3):580-586 [38]Hajishengallis G,Korostoff JM.Response to Comment on "The B Cell-Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell-Dependent Bone Loss in Experimental Murine Periodontitis"[J].J Immunol,2015,195(11):50099-50100 [39]Kwon EY,Cha GS,Jeong E,et al.Pep19 drives epitope spreading in periodontitis and periodontitis-associated autoimmune diseases[J].J Periodontal Res,2016,51(3):381-394 [40]Zhu M,Belkina AC,DeFuria J,et al.B cells promote obesity-associated periodontitis and oral pathogen-associated inflammation[J].J Leukoc Biol,2014,96(2):349-357

B cells in periodontitis immune process??：roles and effects

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