›› 2018, Vol. 38 ›› Issue (1): 78-82.

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Research progress of effects of TGF-βon the development, growth remodeling and degradation of mandibular condylar cartilage

  

  • Received:2017-05-24 Revised:2017-07-02 Online:2018-01-28 Published:2018-01-31

Abstract: Transforming growth factor-β(TGF-β) is a multifunctional cytokine, which performs many crucial cellular functions in cell biological processes such as cell proliferation and differentiation, extracellular matrix synthesis and tissue repair. Recent studies have shown that TGF-βplays an important role in the development of the mandibular condylar cartilage. It mediates local functional stimulus in the remodeling of condylar cartilage and has a potential role in the development of TMJ osteoarthritis, protecting the articular cartilage. The purpose of this review is to discuss effects of TGF-βon the development, remodeling growth and degradation process of mandibular condylar cartilage.

Key words: Transforming Growth Factor beta, Mandibular Condyle, Bone Development, Osteoarthritis

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