Abstract: Chronic periodontal disease is not only accumulated periodontal support tissues, but also related to systemic diseases such as chronic kidney disease. Micro-inflammation is existed in patients with chronic kidney disease, and inflammatory factors are the main effect factor of micro -inflammation . Those factors such as IL - 6, CRP may be involved in the process and development of chronic periodontitis and chronic kidney disease. Take the mechanism of action IL-6, CRP in chronic periodontitis and chronic kidney disease as an example as follows to review briefly.

Key words: chronic periodontitis , chronic kidney disease, Interleukin-6, C-reactive protein