补骨脂素对大鼠正畸复发的生物学影响

Abstract

Abstract: [Abstract] PURPOSE: To figure out the effects of psoralen on orthodontic relapse and GPR30. METHODS: 36 Wistar rats were divided into two groups at random, force appliances were removed after 21 days, then two groups were given psoralen and sodium chloride respectively for 28 days. Measured relapse distance every week. Morphology changes were observed by hematoxylin-eosinstaining. The expression of GPR30 was determined by immunohistochemistry staining. RESULTS: Psoralen group showed lower relapse rate in every detected time, but significant difference was witnessed only in day 7 compared to control group. The expression of GPR30 in psoralen group was significantly higher than control group. CONCLUSIONS: GPR30 is expressed in periodontal tissue. Psoralen could increase the expression of GPR30, stimulate bone generation, and inhibit bone resorption.

Key words: [Keywords] psoralen, relapse, orthodontic tooth movement, G protein coupled receptor30

CLC Number:

R783.5

References

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Biological effects of psoralen on orthodontic relapse in rats

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