牙囊细胞成骨分化的研究进展

Abstract

Abstract: Abstract:The discovery of dental stem cells has received extensive attention because of its significance for the development of novel cellular therapies in dentistry. Dental stem cells are also excellent for studies on cellular processes during dental tissue development or regeneration. Multipotent undifferentiated cells in the dental follicle are one example of dental stem cells, having been used in studies on cellular processes during the differentiation into alveolar osteoblasts and cementoblasts,which are important forperiodontal tissue.This review summarizes current knowledge about the influence of signaling pathways, transcription factors and extracellular matrix proteins on the osteogenic differentiation of DFCs.

Key words: dental follicle cells, osteogenic differentiation, transcription factors, signaling pathways, periodontium

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References

[1]Inan? B.Stem cells in tooth tissue regeneration--challenges and limitations[J].Stem Cell Rev, 2011, 7(3):683-692
[2]Saito M, Handa K, Kiyono T, et al.Immortalization of cementoblast progenitor cells with Bmi-1 and TERT[J].J Bone Miner Res, 2005, 20(1):50-57
[3]Lin GL.Integration of BMP,Wnt,and notch signaling pathways in osteoblast differentiation[J].J Cell Biochem, 2011, 112(12):3491-3501
[4]Chen G, Deng C.TGF-β and BMP signaling in osteoblast differentiation and bone formation[J].Int J Biol Sci, 2012, 8(2):272-288
[5]Viale-Bouroncle S, Felthaus O, Schmalz G, et al.The transcription factor DLX3 regulates the osteogenic differentiation of human dental follicle precursor cells[J].Stem Cells Dev, 2012, 21(11):1936-1947
[6]Viale-Bouroncle S, Klingelhoffer C, Ettl T, et al.A protein kinase A (PKA)β-catenin pathway sustains the BMP2DLX3-induced osteogenic differentiation in dental follicle cells (DFCs)[J].Cell Signal, 2015, 27(3):598-605
[7]Saugspier M, Felthaus O, Viale-Bouroncle S, et al.The differentiation and gene expression profile of human dental follicle cells[J].Stem Cells Dev, 2010, 19(5):707-717
[8]吴艳, 黄兰.骨形态发生蛋白体外诱导牙囊细胞的成骨分化[J].中国组织工程研究, 2015, 19(14):2255-2260
[9]Viale-Bouroncle S, Klingelhoffer C, Ettl T.The WNT inhibitor APCDD1 sustains the expression of β-catenin during the osteogenic differentiation of human dental follicle cells[J].Biochem Biophys Res Commun, 2015, 457(3):314-317
[10]Silverio KG, Davidson KC, James RG, et al.Wntβ-catenin pathway regulates bone morphogenetic protein (BMP2)-mediated differentiation of dental follicle cells[J].J Periodontal Res, 2012, 47(3):309-319
[11]Du Y, Ling J, Wei X, et al.Wntβ-catenin signaling participates in cementoblastosteoblast differentiation of dental follicle cells[J].Connect Tissue Res, 2012, 53(5):390-397
[12]Cho YD, Kim WJ, Yoon WJ, et al.Wnt3a stimulates Mepe,matrix extracellular phosphoglycoprotein,expression directly by the activation of the canonical Wntsignaling pathway and indirectly through the stimulation of autocrine Bmp-2 expression[J].J Cell Physiol, 2012, 227(6):2287-2296
[13]Si W, Kang Q, Luu HH, et al.CCN1Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells[J].Mol Cell Biol, 2006, 26(8):2955-2964
[14]Sakisaka Y, Tsuchiya M, Nakamura T, et al.Wnt5a attenuates Wnt3a-induced alkaline phosphatase expression in dental follicle cells[J].Exp Cell Res, 2015, 336(1):85-93
[15]Liu N, Gu B, Liu N, et al.Wntβ-catenin pathway regulates cementogenic differentiation of adipose tissue-deprived stem cells in dental follicle cell-conditioned medium[J].PloS One, 2014, 9(5):e93364-
[16]Zhang C, Chang J, Sonoyama W, et al.Inhibition of human dental pulp stem cell differentiation by Notch signaling[J].J Dent Res, 2008, 87(3):250-255
[17]Chen X, Zhang T, Shi J, et al.Notch1 signaling regulates the proliferation and self-renewal of human dental follicle cells by modulating the G1S phase transition and telomerase activity[J].PloS One, 2013, 8(7):e69967-
[18]Morsczeck C.Transcriptomes and proteomes of dental follicle cells[J].J Dent Res, 2010, 89(5):445-456
[19]Morsczeck C, Schmalz G, Reichert TE, et al.Gene expression profiles of dental follicle cells before and after osteogenic differentiation in vitro[J].Clin Oral Investig, 2009, 13(4):383-39122
[20]Morsczeck C, Petersen J, V?llner F, et al.Proteomic analysis of osteogenic differentiation of dental follicle precursor cells[J].Electrophoresis, 2009, 30(7):1175-1184
[21]Viale-Bouroncle S, Gosau M.NOTCH1 signaling regulates the BMP2DLX-3 directed osteogenic differentiation of dental follicle cells[J].Biochem Biophys Res Commun, 2014, 443(2):500-504
[22]Wang S, Kawashima N, Sakamoto K, et al.Osteogenic differentiation of mouse mesenchymal progenitor cell,Kusa-A1 is promoted by mammalian transcriptional repressor Rbpj[J].Biochem Biophys Res Commun, 2010, 400(1):39-45
[23]Felthaus O, Oliver F, Viale-Bouroncle S, et al.Transcription factors TP53 and SP1 and the osteogenic differentiation of dental stem cells[J].Differentiation, 2012, 83(1):10-16
[24]Niger C, Lima F, Yoo DJ, et al.The transcriptional activity of osterix requires the recruitment of Sp1 to the osteocalcin proximal promoter[J].Bone, 2011, 49(4):683-692
[25]Zhang Y, Hassan MQ, Xie RL, et al.Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats)[J].J Biol Chem, 2009, 284(5):3125-3135
[26]He Y, de Castro LF, Shin MH, et al.p53 loss increases the osteogenic differentiation of bone marrow stromal cells[J].Stem cells, 2015, 33(4):1304-1319
[27]Despars G, Carbonneau CL, Bardeau P, et al.Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53[J].PloS One, 2013, 8(8):e73206-
[28]Lee SU.POKZBTB proteins: an emerging family of proteins that regulate lymphoid development and function[J].Immunol Rev, 2012, 247(1):107-119
[29]Onizuka S, Iwata T, Park SJ, et al.ZBTB16 as a Downstream Target Gene of Osterix Regulates Osteoblastogenesis of Human Multipotent Mesenchymal Stromal Cells[J].J Cell Biochem, 2016, 117(10):2423-2434
[30]Felthaus O, Gosau M, Klein S, et al.Dexamethasone-related osteogenic differentiation of dental follicle cells depends on ZBTB16 but not Runx2[J].Cell Tissue Res, 2014, 357(3):695-705
[31]Reumann MK, Strachna O, Yagerman S, et al.Loss of transcription factor early growth response gene 1 results in impaired endochondral bone repair[J].Bone, 2011, 49(4):743-752
[32]Reumann MK, Strachna O, Lukashova L, et al.Early growth response gene 1 regulates bone properties in mice[J].Calcif Tissue Int, 2011, 89(1):1-9
[33]Guerquin MJ, Charvet B, Nourissat G, et al.Transcription factor EGR1 directs tendon differentiation and promotes tendon repair[J].J Clin Invest, 2013, 123(8):3564-3576
[34]Press T, Viale-Bouroncle S, Felthaus O, et al.EGR1 supports the osteogenic differentiation of dental stem cells[J].Int Endod J, 2015, 48(2):185-192
[35]Hynes RO.The extracellular matrix: not just pretty fibrils[J].Science, 2009, 326(5957):1216-1219
[36]Holle AW.More than a feeling: discovering,understanding,and influencing mechanosensing pathways[J].Curr Opin Biotechnol, 2011, 22(5):648-654
[37]Watt FM.Role of the extracellular matrix in regulating stem cell fate[J].Nat Rev Mol Cell Biol, 2013, 14(8):467-473
[38]Volloch V.Why cellular stress suppresses adipogenesis in skeletal tissue,but is ineffective in adipose tissue: control of mesenchymal cell differentiation via integrin binding sites in extracellular matrices[J].Matrix Biol, 2013, 32(7-8):365-371
[39]Salasznyk RM, Klees RF, Williams WA, et al.Focal adhesion kinase signaling pathways regulate the osteogenic differentiation of human mesenchymal stem cells[J].Exp Cell Res, 2007, 313(1):22-37
[40]Viale-Bouroncle S, Gosau M.Collagen I induces the expression of alkaline phosphatase and osteopontin via independent activations of FAK and ERK signalling pathways[J].Arch Oral Biol, 2014, 59(12):1249-1255

Research progress in osteogenic differentiation of dental follicle cells

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