Abstract: Objective To investigate the clinical value of PRF and titanium mesh using in dental implantation in aesthetic area.Methods 13 cases with single tooth loss in aesthetic area were selected and divided into two groups. One group(control group ,6 cases) was treated with dental implantation combined with pure artificial bone implantation covered by titanium mesh. The other group(PRF group,7 cases) was treated with dental implantation combined with artificial bone mixed with PRF implantation covered by titanium mesh and PRF membrane. Wound reaction and wound healing were evaluated at the 14th day after operation. After 4 and ahalf months after operation, newly formed bones were harvested for histological observation.ResultsWounds of PRF group were well healedwithout swelling. In contrast, one case of control group had satisfying wound healing. Three cases had wound healing with swelling. Two cases had wound dehiscence with the exposure of titanium mesh. For histological observation, PRF group showed more mature bone formation with more amount of trabecular bones. Conclusion The using of PRF and titanium mesh can improve the newbone formation and reduce the tissue reaction, thus showing a satisfying clinical value in GBR procedure.

Key words: PRF，titanium mesh, GBR