Abstract: Objective To analyze the factors affecting the risk of early childhood caries (ECC) in Nanjing in order to diagnose the ECC, and provide suggestions on prevention and therapy. Methods The baseline data (oral status and venous blood) of caries high-risk children and oral normal children in Department of Perdiatric and Preventive, Affiliated Hospital of Stomatology, Nanjing Medical University were collected. The cavities of all teeth were assessed by using CPI probes according to the Guideline for the 4th National Oral Health Survey. The children’s parents were surveyed by questionnaire. 5ml venous blood of each child was collected. All data were analyzed by univariate and multivariate Logistic regression . Results A total of 199 caries high-risk children were surveyed. The mean age was 3.99±0.99 years old, and 37.2% of them were girls. A total of 164 oral normal children were surveyed. The mean age was 4.14±0.87 years old, and 36.6% of them were girls. Multivariate logistic regression analysis showed that the baseline of total protein (Odds ratio, OR=1.092，95% Confidence interval, CI：1.034~1.155),,serum potassium (OR=2.175，95%CI：1.056~4.48), carbon dioxide (OR=1.32，95%CI：1.194~1.459) and creatine phosphokinase level (OR=1.007，95%CI：1.001~1.014) were more likely associated with risk of ECC. Conclusions The levels of total protein, serum potassium, carbon dioxide and creatine phosphokinase are all higher in caries high-risk children than children without caries, which indicates that these indexes might be the factors affecting the risk of early childhood caries.

Key words: early childhood caries, caries risk, caries highrisk children, influencing factors