牙龈卟啉单胞菌与阿尔茨海默病的相关性研究进展

Abstract

Abstract: Porphyromonas gingivalis is a Gram-negative anaerobe that is the main pathogen of periodontitis. Because of its ability to activate the host inflammatory response and to regulate immune responses, it has been a research hotspot to explore the relationship between P.gingivalis and systemic diseases, especially Alzheimer's disease. AD is a common neurodegenerative disease that causes dementia in the elderly with a variety of inflammatory mediators involved in the inflammatory response as the key pathology. This article reviews their possible interrelated mechanisms.

Key words: Porphyromonas gingivalis, Alzheimer’s disease, inflammatory mediator

CLC Number:

R781.4

References

【1】Grover V, Kapoor A, Malhotra R, Kaur G. Porphyromonas gingivalis antigenic determinants--potential targets for the vaccine development against periodontitis[J]. Infect Disord Drug Targets. 2014,14(1):1-13
【2】Haraguchi A, Miura M, Fujise O, Hamachi T, Nishimura F. Porphyromonas gingivalis gingipain is involved in the detachment and aggregation of Aggregatibacter actinomycetemcomitans biofilm[J]. Mol Oral Microbiol. 2014,29(3):131-143
【3】Wilensky A, Tzach-Nahman R, Potempa J, Shapira L, Nussbaum G. Porphyromonas gingivalis gingipains selectively reduce CD14 expression, leading to macrophage hyporesponsiveness to bacterial infection[J]. Innate Immun. 2015,7(2):127-135
【4】Olsen I, Taubman MA, Singhrao SK. Porphyromonas gingivalis suppresses adaptive immunity in periodontitis, atherosclerosis, and Alzheimer's disease[J]. J Oral Microbiol. 2016, 8(1).
【5】Olsen I, Singhrao S K. Can oral infection be a risk factor for Alzheimer's disease? [J]. J Oral Microbiol, 2015, 7(1):29143.
【6】Hajishengallis G. The inflammophilic character of the periodontitis-associated microbiota[J]. Mol Oral Microbiol. 2014,29(6):248-257
【7】Deleon-Pennell KY, de Castro Brás LE, Lindsey ML. Circulating Porphyromonas gingivalis lipopolysaccharide resets cardiac homeostasis in mice through a matrix metalloproteinase-9-dependent mechanism[J]. Physiol Rep. 2013,1(5):e00079
【8】Chan S, Pasternak GM, West MJ. The place of periodontal examination and referral in general medicine[J]. Periodontol 2000. 2017,74(1):194-199
【9】Alzheimer's Association…2016 Alzheimer's disease facts and figures[J]. Alzheimers Dement. 2016,12(4):459-509
【10】Esparza TJ, Zhao H, Cirrito JR, Cairns NJ, Bateman RJ, Holtzman DM, Brody DL. Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls[J]. Annals of Neurology, 2013, 73(1):104-119.
【11】Heneka MT, Golenbock DT, Latz E. Innate immunity in Alzheimer's disease[J]. Nature Immunology, 2015, 16(3):229.
【12】Spitzer P, Condic M, Herrmann M, Oberstein TJ, Scharin-Mehlmann M, Gilbert DF, Friedrich O, Gr?mer T, Kornhuber J, Lang R, Maler JM. Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity[J]. Sci Rep, 2016, 6:32228.
【13】Kauwe JS, Bailey MH, Ridge PG, et al. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation[J]. PLoS Genet. 2014,10(10):e1004758
【14】Soscia SJ, Kirby JE, Washicosky KJ, et al. The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide[J]. PLoS One. 2010,5(3):e9505
【15】Gokyu M, Kobayashi H, Nanbara H, et al. Thrombospondin-1 production is enhanced by Porphyromonas gingivalis lipopolysaccharide in THP-1 cells[J]. PLoS One. 2014,9(12):e115107
【16】Azizi G, Navabi SS, Al-Shukaili A, Seyedzadeh MH, Yazdani R, Mirshafiey A. The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer's Disease[J]. Sultan Qaboos Univ Med J. 2015,15(3):e305-316
【17】Sparks Stein P, Steffen MJ, Smith C, et al. Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease[J]. Alzheimers Dement. 2012,8(3):196-203
【18】Poole S, Singhrao SK, Kesavalu L, Curtis, M. A.& Crean, S. Determining the presence of periodontopathic virulence factors in short-term postmortem Alzheimer's disease brain tissue[J]. J Alzheimers Dis. 2013,36(4):665-677
【19】Kamer AR, Pirraglia E, Tsui W, et al. Periodontal disease associates with higher brain amyloid load in normal elderly[J]. Neurobiol Aging. 2015,36(2):627-633.
【20】Wu Z, Ni J, Liu Y, Teeling, J. L., Takayama, F., & Collcutt, A. Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice[J]. Brain Behavior & Immunity, 2017, 65:350.
【21】de Souza Rolim T, Fabri GM, Nitrini R, et al. Oral infections and orofacial pain in Alzheimer's disease: a case-control study[J]. J Alzheimers Dis. 2014,38(4):823-829
【22】Singhrao SK, Harding A, Simmons T, et al. Oral inflammation, tooth loss, risk factors, and association with progression of Alzheimer's disease[J]. J Alzheimers Dis. 2014,42(3):723-737
【23】Poole S, Singhrao SK, Chukkapalli S, et al. Active invasion of Porphyromonas gingivalis and infection-induced complement activation in ApoE-/- mice brains[J]. J Alzheimers Dis. 2015,43(1):67-80
【24】Singhrao SK, Chukkapalli S, Poole S, et al. Chronic Porphyromonas gingivalis infection accelerates the occurrence of age-related granules in ApoE-mice brains[J]. J Oral Microbiol. 2017,9(1):1270602
【25】Montagne A, Pa J, Zlokovic BV. Vascular plasticity and cognition during normal aging and dementia[J]. JAMA Neurol.2015,72(5):495-496
【26】Halliday MR, Rege SV, Ma Q, et al. Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease[J]. J Cereb Blood Flow Metab.2016,36(1):216-227
【27】Wu Z, Nakanishi H. Connection between periodontitis and Alzheimer's disease: possible roles of microglia and leptomeningeal cells[J]. J Pharmacol Sci. 2014,126(1):8-13
【28】Bergen A A, Kaing S, ten Brink JB, Bank NB, Gorgels TG. Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer's disease[J]. Bmc Genomics, 2015, 16(1):956.
【29】Chalbot S, Zetterberg H, Blennow K, et al. Blood-cerebrospinal fluid barrier permeability in Alzheimer's disease[J]. J Alzheimers Dis. 2011,25(3):505-515
【30】Ferraz CC, Henry MA, Hargreaves KM, Diogenes A. Lipopolysaccharide from Porphyromonas gingivalis sensitizes capsaicin-sensitive nociceptors[J]. J Endod. 2011,37(1):45-48
【31】Zhang J, Yu C, Zhang X, et al. Porphyromonas gingivalis lipopolysaccharide induces cognitive dysfunction, mediated by neuronal inflammation via activation of the TLR4 signaling pathway in C57BL/6 mice[J]. J Neuroinflammation. 2018,15(1):37
【32】Ye D, Ren J, Yu H, Yu W, Zhou Y. Porphyromonas gingivalis, a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice[J]. Immun Ageing, 2018, 15(1):6.
【33】Olsen I, Singhrao SK. Inflammasome Involvement in Alzheimer's Disease[J]. J Alzheimers Dis.2016,54(1):45-53
【34】Singhrao SK, Harding A, Poole S, Kesavalu L, Crean S. Porphyromonas gingivalis Periodontal Infection and Its Putative Links with Alzheimer's Disease[J]. Mediators of Inflammation, 2015, 2015:1-10.
【35】Bielecka E, Scavenius C, Kantyka T, et al. Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity[J]. J Biol Chem. 2014,289(47):32481-32487

[1]	. Effects of capsaicin on porphyromonas gingivalis growth and inflammatory cytokine secretion in experimental rat periodontitis [J]. , 2017, 37(9): 796-799.
[2]	. The effect of porphyromonas gingivalis lipopolysaccharides on the expression of CD36 and LOX-1 macrophages derived from THP- [J]. , 2015, 35(8): 614-618.

Research Progress on the relation between Porphyromonas gingivalis and Alzheimer's disease

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 2

Recommended Articles

Metrics

Comments