KLF-6在口腔扁平苔藓恶变中的表达研究

Abstract

Abstract: Objective To examine the function of KLF6 in the oral lichen planus pathogenesis and canceration. Methods Immunohistochemistry and Westernblot were used to examine KLF6 protein in 10 cases of normal oral mucosa, 30 cases with oral lichen planus and 22 cases with squamous cell carcinoma. SPSS 14.0 software package was used for t test. Results The expression level of KLF6 protein in 30 cases with oral lichen planus was lower than that in 10 cases with normal oral mucosa and there was significant difference between the two groups(P<0.05).The expression level of KLF6 protein in 22 cases with squamous cell carcinoma was lower than that in 30 cases with oral lichen planus.(P<0.05) and the two groups had significant difference. Conclusions The abnormal expression of KLF6 may play a role in the development and carcinogenesis of OLP.

Key words: oral lichen planus, squamous cell carcinoma, normal oral mucosa

CLC Number:

R781.5

References

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Expression of KLF-6 in the patients with oral lichen planus canceration

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