Abstract: Objective To investigate the changes of hemorheology in patients with oral submucous fibrosis, and to analyze the relationship between the potential factors such as smoking and blood lipid and hemorheology, to explore the role of hemorheology in the pathogenesis of OSF. Methods A total of 57 clinic patients linical and pathological diagnosis of middle OSF were the content of blood viscosity with different shear, plasma viscosity, hematocrit, erythrocyte aggregation index and rigidity index, serum triglyceride (TG) and cholesterol (TC), and the subgroup analysis was applied according to smoking or not , TG and TC content. Results Patients possessing low, medium, high shear viscosity and hematocrit in all 57 patients with OSF were 38 cases (66.7%), 33 cases (57.9%), 22 cases (38.6%) and 38 cases (66.7%) respectively, significantly higher than the control (P<0.01). Plasma viscosity, erythrocyte aggregation index and rigidity index were not abnormal, but they had significant difference compared with the controls (P<0.05). In the subgroup analysis of OSF, the low shear blood viscosity, plasma viscosity and hematocrit of smoking group were higher than non-smoking group.The medium shear viscosity, the high shear viscosity and hematocrit in TC Increased Group were higher than the TC Normal Group. The differences were statistically significant (P<0.05). Conclusion The blood viscosity of patients with OSF is high, and smoking and cholesterol can aggravate high blood viscosity state, suggesting that smoking cessation and low-fat diet combining with blood circulation drugs have certain guiding significance to alleviate the local microcirculatory disorders in OSF patients.

Key words: Oral submucous fibrosis, Hemorheology, Cholesterol, Smoking