Abstract: Objective To assess the experiment effects of blocking therapy combined with mecobalamin on the treatment for patients with primary trigeminal neuralgia. Methods From February 2013 to December 2015， 80 cases (36 males and 44 females，aged from 38 to 82) , diagnosed as primary trigeminal neuralgia , were locally blocked in the neural stem of pain areas , with solution of 2% lidocaine 1.0mL and mecobalamin 2.0 mg (a total of 3.0 mL) ，1 time a day and 7～10 times were one course of treatment in our hospital. Results Among the 80 cases,61 cases were cured,10 cases were improved and 9 cases were in remission after the treatment. No side effects was detected during the whole treatment. Conclusion The blocking therapy combined with mecobalamin is an effective method with wide indications and without side effects in the treatment for trigeminal neuralgia.

Key words: mecobalamin , blocking therapy, trigeminal neuralgia