Abstract: PLGA/PCL-BMP-2 core-shell nanofibrous composite membranes(PP-B) were fabricated by coaxial-electrospinning. Electrospun PLGA/PCL nanofibrous membranes(PP) were set as control group.The structure of core-shell fibers ,cell proliferation and osteogenic diffrretiation on the two membranes were evaluated.This study confirmed that PP-B nanofibrous composite membranes improved the early osteogenic differentiation of MC3T3-E1 cells in vitro.

Key words: bone morphogenetic protein 2, coaxial-electrospinning, tissue engineering scaffold, osteogenic differentiation