›› 2018, Vol. 38 ›› Issue (6): 499-502.

• Basic Research • Previous Articles     Next Articles

Expression and clinical significance of SUZ12 in tongue squamous cell carcinoma

  

  • Received:2017-11-27 Revised:2018-01-04 Online:2018-06-28 Published:2018-07-05

Abstract: Objective  To investigate the expression of SUZ12 in tongue squamous cell carcinoma (TSCC) and its correlation with clinical pathological parameters, to investigate its significance in TSCC treatment and tumor prognosis. Methods Immunohistochemistry was used to examine the expression of SUZ12 in samples from 72 patients with TSCC and 15 normal tongue mucosa. The associations between SUZ12 and multiple clinicopathological parameters and prognosis were analyzed. Results The expression of SUZ12 was significantly higher in TSCC than in normal tongue mucosa. There were no statistically significant differences between the expression levels of SUZ12 and age, sex, smoking, alcohol use, tumor size, pathological grade and clinical stage (P>0.05). However, its over-expression was correlated with cervical node metastasis(P=0.0325), reduced overall survival rate (P=0.0225) and disease-free survival rate(P=0.0179). Conclusions Our data reveal that aberrant SUZ12 over-expression is associated with cervical nodes metastasis and reduced survival rate in TSCC, suggesting that SUZ12 might serve as a novel biomarker with diagnostic and prognostic significance.

Key words: SUZ12, tongue squamous cell carcinoma, immunohistochemistry

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