牙龈卟啉单胞菌刺激树突状细胞激活炎症反应

Abstract

Abstract: Abstract: Objective To analyze differentially expressed genes of dendritic cells infected with Porphyromonas gingivalis and explore the pathogenesis of periodontitis and to provide clues for future research. Methods High-throughput sequencing was used to analyze differentially expressed genes, gene pools and related functions of in vitro induced dendritic cells under P. gingivalis infection. Results A total of 7305 differentially expressed genes with at least two-fold changes were found in this experiment. The results of gene ontology showed that the biological processes, cell components, and molecular functions of dendritic cells after P. gingivalis infection greatly changed. Gene enrichment analysis showed that the tumor necrosis factor gene set, cytokine and inflammatory response gene set, interleukin 1 and NF-kB family of gene transcription factor, interferon signal gene set, B cell receptor signal gene set, T cell receptor signal gene set enriched significantly. Conclusions Dendritic cells can cause genetic changes after P. gingivalis infection, causing the immune response and inflammatory reaction. The levels and effects of CXCL and SOCS could be the direction of future research.

Key words: Porphyromonas gingivalis, Dendritic cells, Periodontitis, Immune response

CLC Number:

R780.2

References

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Porphyromonas gingivalis stimulates dendritic cells to activate inflammatory responses

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