›› 2018, Vol. 38 ›› Issue (7): 592-596.
• Basic Research • Previous Articles Next Articles
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Abstract: Objective To prepare silk fibroin(SF)/polyvinyl alcohol(PVA) / nano-hydroxyapatite (nHA) scaffold and polyvinyl alcohol(PVA) / nano-hydroxyapatite (nHA) scaffold using 3D printing technology and detect their performances. Methods 3D printing technology was used to print SF/PVA/nHA scaffold and PVA/nHA scaffold. Porosity, morphology, mechanical properties and cytotoxicity of different scaffolds were detected. Results ①Under scanning electron microscope, SF/PVA/nHA scaffold had regular scaffold structure and clear network structure, exhibited continuous communicating branch, well-connected overlap joint, and uniform scaffold space. Under the same multiples, the network structure continuity of PVA/nHA scaffold was poorer. ②Compressive mechanical properties: Under the same stress(10 Mpa), the strain of SF/PVA/nHA scaffold was larger than that of PVA/nHA scaffold. ③The pore size of group SF/PVA/nHA scaffold was significantly larger than PVA/nHA scaffold. ④Cell toxicity detection: The deformation of SF/PVA/nHA scaffold ,under the same stress(10 MPa),was larger than PVA/nHA scaffold. There was no significant difference in cell appreciation rate between two groups of scaffolds at different time points. Conclusions 3D printing SF/PVA/nHA scaffold and PVA/nHA scaffold hold good physicochemical performance and cytocompatibility.
Key words: silk fibroin solution, 3D printing, nano-hydroxyapatite
CLC Number:
R781.1
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http://www.stomatology.cn/EN/Y2018/V38/I7/592