›› 2018, Vol. 38 ›› Issue (7): 606-611.

• Basic Research • Previous Articles     Next Articles

Characterization and antibacterial effects of novel PLGA-HA-Bioglass composite membranes

  

  • Received:2017-11-09 Revised:2017-12-22 Online:2018-07-28 Published:2018-07-28
  • Contact: Ya-Ming Chen E-mail:dentistyamingchen@126.com

Abstract: Objective  To fabricate and assess the PLGA/HA/BAG composite membranes as a brand-new control-releasing delivery system in treatment of periodontitis. Methods The PLGA/HA/BAG composite films were synthesized by a solvent-evaporation method. SEM was utilized for the morphology and mass loss during the immersion, ion release and changes in pH were also analyzed. The immersion of the films and pristine BAG powder were extracted, between which the efficiency of antibacterial effect was compared with MTT assay. CCK-8 kit was employed to evaluate the cytotoxicity with human periodontal ligament fibroblast cells. Results The film had longer antibacterial effects against Porphyromonas gingivalis (ATCC 33277) and Actinobacillus actinomycetemcomitans (ATCC 29523) than powder. Conclusion The film has great potentials of being a treatment for periodontitis in the future.

Key words: PLGA, hyaluronic acid, bioactive glass, composite film, antibacterial

CLC Number: