MMP-14在口腔癌患者预后及转移的临床病理学研究

Abstract

Abstract: Objective To study the expressions of MMP-14 (matrix metalloproteinase-14), Vimentin and E-cadherin in oral squamous cell carecinoma (OSCC) and to investigate the relationship between MMP-14, Vimentin and E-cadherin expression and pathologic diagnosis, clinicopathogical features and prognosis. Methods The expression levels of MMP-14, Vimentin and E-cadherin were tested by immunohistochemical in 83 cases of OSCC and 20 in adjacent normal tissues, and statistical analysis was conducted according to the clinical parameters of follow-up patients. Results The expression level of MMP-14 protein in the OSCC tissue was significantly higher than that in the surrounding normal tissue (P<0.01). In OSCC tissue, the MMP-14 expression was positively correlated with lymph node metastasis(P<0.01), low differentiated degree(P<0.05), and the T3-T4 tumor stage(P<0.05). MMP-14 showed significant positive correlation with Vimentin, and negative correlation with E-cadherin (P<0.01). Conclusion This study has found the close relationship between high expression of MMP-14 in oral carcinoma and the recurrence and prognosis. Epithelial-mesenchymal transition may promote invasion and metastasis of oral carcinoma, and MMP-14 promotes EMT.

Key words: oral squamous cell carcinoma, MMP-14, EMT, immunohistochemistry

CLC Number:

R730.2

References

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A clinicopathological study of the prognosis and metastasis of MMP-14 in oral cancer patients

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