Abstract: Objective To investigate the efficacy and safety of Dentium oral repair membrane guided bone regeneration in dental implants. Methods A total of 148 dental implants in our hospital from October 2015 to October 2017 were selected and divided into 2 groups according to the random number table (74 cases). In the control group, bone regeneration was guided with titanium membrane, and in the observation group, the regeneration of bone was guided with the oral cavity repair membrane. The bone growth and complication rates were compared between the two groups. Results The bone growth in the observation group was better than that in the control group and there was statistical difference(P<0.05). The incidence of complications in the observation group was lower than that in the control group and the difference was statistically significant (P<0.05). Conclusion Dentium oral repair membrane guide bone regeneration applied to dental implants patients can effectively improve the bone growth effect and reduce the incidence of complications, whose application is worth promoting.