Abstract: Most tissue engineering approaches attempt to improve the regenerative effect after injury by combining stem cells with biocompatible materials and bioactive factors. The main components of bone tissue engineering are seeding cells, scaffolds and growth factors. The scaffold material is implanted into the bone tissue injury site, which can enhance the osteogenic ability of cells, improve the ability of bone tissue growth, thus promoting bone tissue regeneration. However, the implanted material may cause the host’s immune response, affect the results of bone tissue regeneration. This review summarizes the effects of scaffold-induced tissue immune response on bone tissue regeneration.

Key words: scaffolds, immune response, bone tissue regeneration