Abstract: The alveolar bone defect in oral and maxillofacial surgery is the main cause of oral dysfunction, how to repair bone defect and restore its function is the focus in recent years. The current clinical technology based on the use of bone reconstruction have certain limitations, then tissue engineering and bone mesenchymal regenerative medicine came into being. Because of the proliferation and differentiation of mesenchymal stem cells ，MSCs can replace the damaged tissue, it is expected to become an effective alternative for the treatment of bone defect. Recent studies have shown that mesenchymal stem cells can secrete growth factors, these growth factors play an important role in the process of repair and regeneration of tissues. This indicates that the mode based on the proliferation and differentiation of mesenchymal stem cells to repair bone defect have turn to another direction, namely the mesenchymal stem cell paracrine growth factor induced bone repair. This paper summarizes the recent basic research of bone defect repair and clinical experimental results, focus on the new direction of mesenchymal stem cells paracrine effects of bone repair treatment and related growth factors.

Key words: mesenchymal stem cells, growth factor, alveolar bone repair