Abstract: Objective　To summarize the clinical, pathological characteristics and treatment of Castleman’s disease (CD) in oral, maxillofacial and neck region. Methods　The CD cases in oral maxillofacial and neck region treated in Affiliated Stomatological Hospital, Nanjing Medical University from 2007 to 2017 were identified. The relevant clinicopathological and follow-up data were collected and presented. Results　Six cases of CD were identified with the histopathological subtype as hyaline-vascular type. Surgical resection of these masses was performed in all cases. No evidence of disease recurrence was found during the follow-up ranging from 2 months to 9 years. Conclusions　Castleman disease rarely occurs in oral, maxillofacial and neck region and its diagnosis relies on pathological examination. Surgical resection is a primary treatment with favorable prognosis.

Key words: Castleman’s Disease, head and neck, clinical presentation, diagnosis, Prognosis