Abstract: Guided bone regeneration(GBR) is an important method to repair defects around the implant, but there are still deficiencies in the effect of bone formation. In theory, the application of growth factors and bioactive materials to GBR in tissue engineering can improve the efficacy. However, at present, there are no clinical predictable therapies for the regeneration of defects around the implant. Even some studies have found that the long-term stability of osteogenesis after the use of growth factors in GBR is not consistent with the theoretically expected results. This problem must be solved to advance the application of growth factors. Through literature review and analysis, two possible reasons are given in the paper: the level of growth factor is too low in later phase and the degradation of the barrier membrane is accelerated by the growth factors. Based on this, the verification method is proposed to provide reference and basis for further research.

Key words: guided bone regeneration, tissue engineering, growth factor, barrier membrane