牙髓血管再生的相关研究进展

Abstract

Abstract: In recent years, the direction and research hotspot of the treatment of pulpal and periapical diseases has been focused from traditional root canal therapy to pulp tissue regeneration. Pulp tissue regeneration includes nerve regeneration, revascularization, dentin regeneration and so on. This paper reviews the research progress of the related factors, cells and microenvironment of pulp revascularization.

Key words: revascularization, vascular factors, cells, microenvironment

CLC Number:

R329.1

References 34

[1]	Goldberg, M, Njeh A, Uzunoglu E.Uzunoglu.Is Pulp Inflammation a Prerequisite for Pulp Healing and Regeneration[J]? Mediators of Inflammation, 2015, 1:1-11.[J].Mediators of Inflammation, 2015, 1:1-11
[2]	Takehiko Yamamura.Differentiation of pulpal cells and inductive influences of various matrices with reference to pulpal wound healing [J]. J Dent Res, 1985, 64:530–540.[J]. J Dent Res, 1985, 64:530-540
[3]	Roberts-Clark DJ, Smith AJ.Angiogenic growth factors in human dentine matrix[J].Arch Oral Biol., 2000, 45(11):1013-1016
[4]	Mathieu S, El-Battari A, Dejou J, et al.Role of injured endothelial cells in there cruitment of human pulp cells[J].Arch Oral Biol, 2005, 50(2):109-113
[5]	Tran-Hung L, Mathieu S, About I.Role of human pulp fibroblasts in angiogenesis[J].J Dent Res, 2006, 85(9):819-823
[6]	Alkharobi H, Beattie J, Meade J, et al .Dental Pulp Cells Isolated from Teeth with Superficial Caries Retain an Inflammatory Phenotype and Display an Enhanced Matrix Mineralization Potential[J]. Front. Physiol. 2017, 8:244.[J].Front. Physiol, 2017, 8:244-
[7]	刘庆娜.低氧对人牙髓干细胞生物学特性的影响[D].南方医科大学, 2015.
[8]	Yuan C, Wang P, Zhu L, et al.Coculture of stem cells from apical papilla and human umbilical vein endothelial cell under hypoxia increases the formation of three-dimensional vessel-like structures in vitro[J]. Tissue Engineering Part A, 2015, 21:1163–1172.[J].Tissue Engineering Part A, 2015, 21:1163-1172
[9]	Zimna A, Kurpisz M.Hypoxia-inducible factor-1 in physiological and pathophysiological angiogenesis: applications and therapies[J]. Biomed Res Int, 2015.
[10]	史诗彧, 谢家敏.牙髓干细胞在组织工程领域的研究进展[J].华西口腔医学杂志, 2015, 33(6):656-659
[11]	Hilkens P, Fanton Y, Martens W, et al.Pro-angiogenic impact of dental stem cells in vitro and vivo[J].Stem Cell Res. 2014, 12:778–790.
[12]	Bronckaers A, Hilkens P, Fanton Y, et al.Angiogenic properties of human dental pulp stem cells[J].PLoS One. 2013, 8:244.
[13]	Liu, M, Zhao, L, Hu, J, et al .Endothelial cells and endothelin?1 promote the odontogenic differentiation of dental pulp stem cells[J]. Molecular Medicine Reports .2018, 18(1): 893-901.
[14]	Dissanayaka Waruna Lakma, Hargreaves Kenneth M., Jin Li, et al . The interplay of dental pulp stem cells and endothelial cells in an injectable peptide hydrogel on angiogenesis and pulp regeneration in vivo[J]. Tissue Engineering Part A. 2015, 21.
[15]	Janebodin K, Zeng Y, Buranaphatthana W, et al.VEGFR2-dependent angiogenic capacity of pericyte-like dental pulp stem cells[J]. J Dent Res, 2013, 92:524–531.
[16]	谷楠, 孙鑫, 刘富萍, 等.脱落乳牙牙髓干细胞的生物学特性[J].国际口腔医学杂志, 2015, 42(06):715-719
[17]	Cordeiro MM, Dong Z, Kaneko T, et al.Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth[J]. J Endod, 2008, 34:962–969.
[18]	Kunimatsu R, Nakajima K, Awada T, et al, Comparative characterization of stem cells from human exfoliated deciduous teeth, dental pulp, and bone marrow–derived mesenchymal stem cells[J].Biochemical and Biophysical Research Communications, 2018, 501(1): 193-198.
[19]	Bento LW, Zhang Z, Imai A, et al.Endothelial differentiation of SHED requires MEK1/ERK signaling[J]. J Dent Res, 2013, 92:51–57.
[20]	Hayashi Y, Murakami M, Kawamura R, et al.CXCL14 and MCP1 are potent trophic factors associated with cell migration and angiogenesis leading to higher regenerative potential of dental pulp side population cells[J].Stem Cell Research & Therapy, 2015, 6(1):111-
[21]	Iohara K, Zheng L, Ito M, et al.Regeneration of dental pulp after pulpotomy by transplantation of CD31(-)CD146(-) side population cells from a canine tooth[J].Regen Med, 2009, 4(3):377-385
[22]	Ishizaka, R, Y Hayashi， K Iohara，et al.Stimulation of angiogenesis,neurogenesis and regeneration by side population cells from dental pulp[J].Biomaterials, 2013, 34(8):1888-1897
[23]	Yadlapati M.Characterization of a Vascular Endothelial Growth Factor–loaded Bioresorbable Delivery System for Pulp Regeneration[J].J Endod, 2017, 43(1):77-83
[24]	Zhang Z, N?r F, Oh M, et al.Wntβ-Catenin Signaling Determines the Vasculogenic Fate of Postnatal Mesenchymal Stem Cells[J].Stem Cells, 2016, 34(6):1576-1587
[25]	Tran-Hung L, Mathieu S, About I.Role of human pulp fibroblasts in angiogenesis[J]. J Dent Res, 2006, 85:819–823.
[26]	Takeuchi N, Hayashi Y, Murakami M, et al.Similar in vitro effects and pulp regeneration in ectopic tooth transplantation by basic fibroblast growth factor and granulocyte-colony[J]. Oral Dis, 2015, 21：113–122.
[27]	Tran-Hung L, Laurent P, Camps J, et al.Quantification of angiogenic growth factors released by human dental cells after injury[J]. Arch Oral Biol, 2008, 53:9–13.
[28]	Demarco FF, Conde MC, Cavalcanti BN, et al.Dental pulp tissue engineering[J].Braz Dent J, 2011, 22(1):3-13
[29]	Ding RY, Cheung GS, Chen J, et al.Pulp revascu-larization of immature teeth with apical periodontitis: a clinical study[J].J Endod, 2009, 35(5):745-749
[30]	Mullane EM, Dong Z, Sedgley CM, et al.Effects of VEGF and FGF2 on the revascularization of severed human dental pulps[J].J Dent Res, 2008, 87(12):1144-1148
[31]	Kim JY, Xin X, Moioli EK, et al.Regeneration of dental-pulp-like tissue by chemotaxis-induced cell homing[J].Tissue Eng Part A, 2010, 16(10):3023-3031
[32]	Chen YJ, Zhao YH, Zhao YJ, et al.Potential dental pulp revascularization and odonto-osteogenic capacity of a novel transplant combined with dental pulp stem cells and platelet-rich fibrin[J].Cell Tissue Res, 2015, 361(2):439-455
[33]	Li X, Ma C, Xie X, et al.Pulp regeneration in a full-length human tooth root using a hierarchical nanofibrous microsphere system[J].Acta Biomater, 2016, 35:57–67.[J].Acta Biomater, 2016, 35:57-67
[34]	Soares, D.G.Simvastatin and nanofibrous poly(l-lactic acid) scaffolds to promote the odontogenic potential of dental pulp cells in an inflammatory environment[J]. Acta Biomaterialia, 2018, 68:190-203.

Research progress on dental pulp vessel regeneration

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