软骨内成骨修复骨损伤的调节机制

Abstract

Abstract: Endochondral ossification is one of the main modes of bone repair, which follows specific biological steps and involves complex regulatory mechanisms. Currently, it has attracted particular attention in the field of regenerative medicine. A better understanding into the mechanism of endochondral ossification, will allow us to devise strategies to improve bone regeneration. In this context, we reviewed the regulation mechanism of osteochondral ossification in bone repair.

Key words: bone repair, endochondral ossification, mechanism

CLC Number:

R336

References 53

[1]	Zhang T, Xie J, Sun K et al.Physiological oxygen tension modulates soluble growth factor profile after crosstalk between chondrocytes and osteoblasts[J].Cell Prolif, 2016, 49(1):122-133
[2]	Bardsley K, Kwarciak A, Freeman C et al.Repair of bone defects in vivo using tissue engineered hypertrophic cartilage grafts produced from nasal chondrocytes[J]. Biomaterials, 2017, 112：313-323.[J].Biomaterials, 2017, 112:313-323
[3]	Hasegawa S, Kitoh H, Ohkawara B et al.Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters[J].Biochem Biophys Res Commun, 2016, 470(2):356-361
[4]	Martin S J.Cell death and inflammation: the case for IL-1 family cytokines as the canonical DAMPs of the immune system[J].FEBS J, 2016, 283(14):2599-2615
[5]	Kovtun A, Bergdolt S, Wiegner R et al.The crucial role of neutrophil granulocytes in bone fracture healing[J]. European Cells and Materials, 2016, 32:152-162.
[6]	Bastian O, Pillay J, Alblas J et al.Systemic inflammation and fracture healing[J].J Leukoc Biol, 2011, 89(5):669-673
[7]	Hurst SM1, Wilkinson TS, McLoughlin RM et al.IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation[J].Immunity, 2001, 14(6):705-714
[8]	Xing Z, Lu C, Hu D et al.Multiple roles for CCR2 during fracture healing[J].Dis Model Mech, 2010, 3(7-8):451-458
[9]	Schlundt C, El Khassawna T, Serra A et al.Macrophages in bone fracture healing: Their essential role in endochondral ossification[J]. Bone, 2018, 106:78-89.
[10]	Wu A C, Raggatt L J, Alexander K A et al.Unraveling macrophage contributions to bone repair[J]. Bonekey Rep, 2013, 2:373.
[11]	Pajarinen J, Lin T, Gibon E et al.Mesenchymal stem cell-macrophage crosstalk and bone healing[J]. Biomaterials, 2018, pii: S0142-9612(17)30834-7.
[12]	Loi F, Cordova L A, Pajarinen J et al.Inflammation, fracture and bone repair[J]. Bone, 2016, 86:119-130.
[13]	Granero-Molto F, Weis J A, Miga M I et al.Regenerative effects of transplanted mesenchymal stem cells in fracture healing[J].Stem Cells, 2009, 27(8):1887-1898
[14]	Murao H, Yamamoto K, Matsuda S et al.Periosteal cells are a major source of soft callus in bone fracture[J].J Bone Miner Metab, 2013, 31(4):390-398
[15]	Ahmadian Kia N, Bahrami A R, Ebrahimi M et al.Comparative analysis of chemokine receptor's expression in mesenchymal stem cells derived from human bone marrow and adipose tissue[J].J Mol Neurosci, 2011, 44(3):178-185
[16]	Liu H, Li M, Du L et al.Local administration of stromal cell-derived factor-1 promotes stem cell recruitment and bone regeneration in a rat periodontal bone defect model[J]. Mater Sci Eng C Mater Biol Appl, 2015, 53:83-94.
[17]	Ho C Y, Sanghani A, Hua J et al.Mesenchymal stem cells with increased stromal cell-derived factor 1 expression enhanced fracture healing[J].Tissue Eng Part A, 2015, 21(3-4):594-602
[18]	Crane J L & Cao X.Bone marrow mesenchymal stem cells and TGF-beta signaling in bone remodeling[J].J Clin Invest, 2014, 124(2):466-472
[19]	Haasters F, Docheva D, Gassner C et al.Mesenchymal stem cells from osteoporotic patients reveal reduced migration and invasion upon stimulation with BMP-2 or BMP-7[J].Biochem Biophys Res Commun, 2014, 452(1):118-123
[20]	Dimitriou R, Tsiridis E & Giannoudis P V.Current concepts of molecular aspects of bone healing[J].Injury, 2005, 36(12):1392-1404
[21]	Einhorn TA .The cell and molecular biology of fracture healing[J]. Clin Orthop Relat Res., 1998, (355 Suppl):S7-S21.
[22]	Raheja L F, Genetos D C & Yellowley C E.The effect of oxygen tension on the long-term osteogenic differentiation and MMPTIMP expression of human mesenchymal stem cells[J].Cells Tissues Organs, 2010, 191(3):175-184
[23]	Burke D, Dishowitz M, Sweetwyne M et al.The role of oxygen as a regulator of stem cell fate during fracture repair in TSP2-null mice[J].J Orthop Res, 2013, 31(10):1585-1596
[24]	Chen M J, Whiteley J P, Please C P et al.Inducing chondrogenesis in MSC/chondrocyte co-cultures using exogenous TGF-beta: a mathematical model[J]. J Theor Biol, 2018, 439:1-13.
[25]	Branly T, Bertoni L, Contentin R et al.Characterization and use of Equine Bone Marrow Mesenchymal Stem Cells in Equine Cartilage EngineeringStudy of their Hyaline Cartilage Forming Potential when Cultured under Hypoxia within a Biomaterial in the Presence of BMP-2 and TGF-ss1[J].Stem Cell Rev, 2017, 13(5):611-630
[26]	Claes L, Recknagel S & Ignatius A.Fracture healing under healthy and inflammatory conditions[J].Nat Rev Rheumatol, 2012, 8(3):133-143
[27]	Gomez-Gaviro M V, Lovell-Badge R, Fernandez-Aviles F et al.The vascular stem cell niche[J].J Cardiovasc Transl Res, 2012, 5(5):618-630
[28]	Bahney C S, Hu D P, Miclau T 3rd et al.The multifaceted role of the vasculature in endochondral fracture repair[J]. Front Endocrinol (Lausanne), 2015, 6:4.
[29]	Stegen S, van Gastel N & Carmeliet G.Bringing new life to damaged bone: the importance of angiogenesis in bone repair and regeneration[J]. Bone, 2015, 70:19-27.
[30]	Hu K & Olsen B R.The roles of vascular endothelial growth factor in bone repair and regeneration[J]. Bone, 2016, 91:30-38.
[31]	Hu K & Olsen B R.Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair[J].J Clin Invest, 2016, 126(2):509-526
[32]	Ahn GO, Seita J, Hong BJ et al.Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8[J].Proc Natl Acad Sci U S A, 2014, 111(7):2698-2703
[33]	Drager J, Harvey E J & Barralet J.Hypoxia signalling manipulation for bone regeneration[J]. Expert Rev Mol Med, 2015, 17: e6.
[34]	Li L, Qu Y, Jin X et al.Protective effect of salidroside against bone loss via hypoxia-inducible factor-1alpha pathway-induced angiogenesis[J]. Sci Rep, 2016, 6: 32131.
[35]	Kozhemyakina E, Lassar A B & Zelzer E.A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation[J].Development, 2015, 142(5):817-831
[36]	Phillips A M.Overview of the fracture healing cascade[J]. Injury, 2005, 36 Suppl 3:S5-S7.
[37]	Cooper K L, Oh S, Sung Y et al.Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions[J].Nature, 2013, 495(7441):375-378
[38]	Lefebvre V & Smits P.Transcriptional control of chondrocyte fate and differentiation[J].Birth Defects Res C Embryo Today, 2005, 75(3):200-212
[39]	Asmussen N, Lin Z, McClure M J et al.Regulation of extracellular matrix vesicles via rapid responses to steroid hormones during endochondral bone formation[J]. Steroids, 2017, pii: S0039-128X(17)30229-5.
[40]	Yadav M C, Bottini M, Cory E et al.Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in Phospho1(--) and Phospho1Pi t1 Double-Knockout Mice[J].J Bone Miner Res, 2016, 31(6):1275-1286
[41]	Bottini M, Mebarek S, Anderson K L et al.Matrix vesicles from chondrocytes and osteoblasts: Their biogenesis,properties,functions and biomimetic models[J].Biochim Biophys Acta Gen Subj, 2018, 1862(3):532-546
[42]	Mueller M B & Tuan R S.Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells[J].Arthritis Rheum, 2008, 58(5):1377-1388
[43]	Ortega N, Wang K, Ferrara N et al.Complementary interplay between matrix metalloproteinase-9,vascular endothelial growth factor and osteoclast function drives endochondral bone formation[J].Dis Model Mech, 2010, 3(3-4):224-235
[44]	Yang G, Zhu L, Hou N et al.Osteogenic fate of hypertrophic chondrocytes[J].Cell Res, 2014, 24(10):1266-1269
[45]	Yang L, Tsang K Y, Tang H C et al.Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation[J].Proc Natl Acad Sci U S A, 2014, 111(33):12097-12102
[46]	Park J, Gebhardt M, Golovchenko S et al.Dual pathways to endochondral osteoblasts: a novel chondrocyte-derived osteoprogenitor cell identified in hypertrophic cartilage[J].Biol Open, 2015, 4(5):608-621
[47]	Hinton R J, Jing Y, Jing J et al.Roles of Chondrocytes in Endochondral Bone Formation and Fracture Repair[J].J Dent Res, 2017, 96(1):23-30
[48]	Bahney C S, Hu D P, Taylor A J et al.Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation[J].J Bone Miner Res, 2014, 29(5):1269-1282
[49]	Kalbasi Anaraki P, Patecki M, Tkachuk S et al.Urokinase receptor mediates osteoclastogenesis via M-CSF release from osteoblasts and the c-FmsPI3KAktNF-kappaB pathway in osteoclasts[J].J Bone Miner Res, 2015, 30(2):379-388
[50]	Honma M, Ikebuchi Y, Kariya Y et al.Regulatory mechanisms of RANKL presentation to osteoclast precursors[J].Curr Osteoporos Rep, 2014, 12(1):115-120
[51]	Sapir-Koren R & Livshits G.Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles?[J].Osteoporos Int, 2014, 25(12):2685-2700
[52]	Xiong J, Piemontese M, Thostenson J D et al.Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency[J]. Bone, 2014, 66: 146-154.
[53]	Thudium CS, Moscatelli I, Flores C, et al.A Comparison of Osteoclast-Rich and Osteoclast-Poor Osteopetrosis in Adult Mice Sheds Light on the Role of the Osteoclast in Coupling Bone Resorption and Bone Formation [J]. Calcif Tissue Int. 2014, 95(1):83-93.

Regulation mechanism of endochondral ossification in bone injury repair

Knowledge

Abstract

Cite this article

share this article

References 53

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	. Progress of mesenchymal stem cell related growth factor in alveolar bone repair [J]. , 2019, 39(1): 66-70.
[2]	. Research progress of laser in the treatment of dentin hypersensitivity [J]. , 2018, 38(3): 277-280.
[3]	. Research and Progerss of Calcium Phosphate Cement with silicon [J]. , 2018, 38(10): 942-946.
[4]	. Effect and mechanism of nano-hydroxyapatite on bone regeneration [J]. , 2017, 37(5): 453-456.
[5]	. Research progress of the signaling pathway related to temporomandibular disorders [J]. , 2017, 37(12): 1139-1143.
[6]	. Allogeneic bone material and its application in the extraction site preservation. [J]. , 2017, 37(11): 1034-1037.
[7]	. Application and research progress of antimicrobial activity of zinc oxide nanoparticles in medicine [J]. , 2017, 37(11): 1045-1048.
[8]	. Antibacterial mechanism and influencing factors of photocatalytic nano-titanium dioxide materials [J]. , 2017, 37(1): 81-84.
[9]	. Preliminary exploration of the mechanism of a two-incision fistula technique for the treatment of oral ranulas. [J]. , 2016, 36(9): 806-808.
[10]	. Research of the cellular uptake mechanism of nanoparticles and its influencing factors [J]. , 2016, 36(6): 573-576.
[11]	. Research progress of effects of Naringin on osteogenic induction [J]. , 2016, 36(3): 277-280.
[12]	. Effects and mechanism of oxidative stress induced pathogenesis of diabetesrelated periodontitis [J]. , 2016, 36(3): 273-276.
[13]	. Research progress of orthodontic pain [J]. , 2015, 35(5): 412-416.
[14]	. Roles of EMT in the pathologic mechanism of oral squamous cell carcinoma and lichen planus [J]. , 2015, 35(4): 296-301.
[15]	Fang WANG. Research progress on the osteogenic mechanisms of parathyroid hormone and its effect on craniomaxillofacial and periodontal tissue regeneration [J]. , 2015, 35(12): 1076-1079.