PI3K/AKT通路介导口腔鳞状细胞癌发生发展相关因素的研究进展

Abstract

Abstract: Oral cancer is a malignant tumor of the lips or mouth. It is one of the 10 most common cancers in the world. 90% of oral cancer cases are Oral squamous cell carcinoma (OSCC) . PI3K/AKT signal transduction pathway is one of the important signal transduction pathways in cells, and has close relationship with the occurrence and development of many malignant tumors (including OSCC) . This article mainly reviews the PI3K/AKT pathway mediating the occurrence, development and metastasis of oral squamous cell carcinoma.

Key words: oral squamous cell carcinoma, PI3K/AKT pathway, mTOR

CLC Number:

R739.8

References 26

[1]	Benhamou Y, Picco V, Pagès G.The telomere proteins in tumorigenesis and clinical outcomes of oral squamous cell carcinoma[J].Oral oncology, 2016, 4(57):46-53
[2]	Dikshit R, Gupta P C, Ramasundarahettige C, et al.Cancer mortality in India: a nationally representative survey[J].The Lancet, 2012, 379(9828):1807-1816
[3]	Simpson D R, Mell L K, Cohen E E W.Targeting the PI3KAKTmTOR pathway in squamous cell carcinoma of the head and neck[J].Oral oncology, 2015, 51(4):291-298
[4]	Pal I, Mandal M.PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes[J].Acta Pharmacologica Sinica, 2012, 33(12):1441-1458
[5]	Thorpe L M, Yuzugullu H, Zhao J J.PI3K in cancer: divergent roles of isoforms,modes of activation and therapeutic targeting[J].Nature Reviews Cancer, 2015, 15(1):7-24
[6]	Abeyrathna P, Su Y.The critical role of Akt in cardiovascular function[J].Vascular pharmacology, 2015, 5(74):38-48
[7]	Nitulescu G M, Margina D, Juzenas P, et al.Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use[J].International journal of oncology, 2016, 48(3):869-885
[8]	Martins F, Sousa S C O M, Santos E, et al.PI3K–AKT–mTOR pathway proteins are differently expressed in oral carcinogenesis[J].Journal of Oral Pathology & Medicine, 2016, 45(10):746-752
[9]	Cai Y, Dodhia S, Su G H.Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinoma[J].Oncotarget, 2017, 8(13):22203-22217
[10]	Tu H F, Chang K W, Chiang W F, et al.The frequent co-expression of the oncogenes PIK3CA and PAK1 in oral carcinomas[J].Oral oncology, 2011, 47(3):211-216
[11]	Sento S, Sasabe E, Yamamoto T.Application of a persistent heparin treatment inhibits the malignant potential of oral squamous carcinoma cells induced by tumor cell-derived exosomes[J].PloS one, 2016, 11(2):e0148454-20
[12]	Vander Broek R, Mohan S, Eytan D F, et al.The PI3KAktmTOR axis in head and neck cancer: functions,aberrations,cross‐talk,and therapies[J].Oral diseases, 2015, 21(7):815-825
[13]	Pereira‐Castro I, Costa ? M S, Oliveira M J, et al.Characterization of human NLZ1ZNF703 identifies conserved domains essential for proper subcellular localization and transcriptional repression[J].Journal of cellular biochemistry, 2013, 114(1):120-133
[14]	Springer S, Kyung H Y, Park J, et al.Engineering targeted chromosomal amplifications in human breast epithelial cells[J].Breast cancer research and treatment, 2015, 152(2):313-321
[15]	Baltaci E, Karaman E, Dalay N, et al.Analysis of gene copy number changes in head and neck cancer[J]. Clinical Otolaryngology, 2016.
[16]	Pereira F, Duarte-Pereira S, Silva R M, et al.Evolution of the NET (NocA, Nlz, Elbow, TLP-1) protein family in metazoans: insights from expression data and phylogenetic analysis[J].Scientific reports, 2016, 6(38383):1-12
[17]	Wang H, Deng X, Zhang J, et al.Elevated Expression of Zinc Finger Protein 703 Promotes Cell Proliferation and Metastasis through PI3KAKTGSK-3β Signalling in Oral Squamous Cell Carcinoma[J].Cellular Physiology and Biochemistry, 2017, 44(3):920-934
[18]	Tarquinio S B C, Zhang Z, Neiva K G, et al.Endothelial cell Bcl‐2 and lymph node metastasis in patients with oral squamous cell carcinoma[J].Journal of Oral Pathology & Medicine, 2012, 41(2):124-130
[19]	Wang K, Lin C, Wang C, et al.Silencing Kif2a induces apoptosis in squamous cell carcinoma of the oral tongue through inhibition of the PI3KAkt signaling pathway[J].Molecular medicine reports, 2014, 9(1):273-278
[20]	Lee C C, Shiao H Y, Wang W C, et al.Small-molecule EGFR tyrosine kinase inhibitors for the treatment of cancer[J].Expert opinion on investigational drugs, 2014, 23(10):1333-1348
[21]	Jeon Y J, Cho J H, Lee S Y, et al.Esculetin induces apoptosis through EGFRPI3KAkt signaling pathway and nucleophosmin relocalization[J].Journal of cellular biochemistry, 2016, 117(5):1210-1221
[22]	Lee M F, Chan C Y, Hung H C, et al.N-acetylcysteine (NAC) inhibits cell growth by mediating the EGFRAktHMG box-containing protein 1 (HBP1) signaling pathway in invasive oral cancer[J].Oral oncology, 2013, 49(2):129-135
[23]	de Brachène A C, Bollaert E, Eijkelenboom A, et al.The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3KPKBFOXO pathway[J].Biochemical Journal, 2014, 460(1):25-36
[24]	Chan C Y, Huang S Y, Sheu J J C, et al.Transcription factor HBP1 is a direct anti-cancer target of transcription factor FOXO1 in invasive oral cancer[J].Oncotarget, 2017, 8(9):14537-14548
[25]	Wang H, Wu Q, Liu Z, et al.Downregulation of FAP suppresses cell proliferation and metastasis through PTENPI3KAKT and Ras-ERK signaling in oral squamous cell carcinoma[J].Cell death & disease, 2014, 5(4):e1155-11
[26]	Peng B, Gu Y, Xiong Y, et al.Microarray-assisted pathway analysis identifies MT1X & NFκB as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma[J].PloS one, 2012, 7(12):e51413-13

Advances in the study of factors related to the occurrence and development of oral squamous cell carcinoma mediated by PI3K/AKT pathway

Knowledge

Abstract

Cite this article

share this article

References 26

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	. Inhibitory effect of danshensu on oral squamous cell carcinoma CAL-27 cells in vitro [J]. , 2019, 39(2): 113-116.
[2]	. A clinicopathological study of the prognosis and metastasis of MMP-14 in oral cancer patients [J]. , 2018, 38(8): 685-689.
[3]	. DNA quantitative analysis of oral squamous cell carcinoma and its clinical significance [J]. , 2018, 38(7): 616-619.
[4]	. Influence of nobelitin on the proliferation，migration and invasion of oral squamous cell carcinoma Cal-27 cells [J]. , 2018, 38(6): 481-484.
[5]	. Non-invasive Human Papilloma Virus Detection of Oral leukoplakia and Squamous Cell Carcinomas [J]. , 2018, 38(6): 528-532.
[6]	. Expression regulation of microRNA and oral squamous cell carcinoma [J]. , 2018, 38(5): 476-480.
[7]	. Relationship between E-cadherin and MMP-1 expressions and prognosis in oral squamous cell carcinoma [J]. , 2018, 38(1): 39-43.
[8]	. Effect of staurosporine on cell proliferation and apoptosis in oral squamous cell carcinoma cell line CAL27 [J]. , 2017, 37(7): 598-602.
[9]	chen xin. Current situation of oral squamous cell carcinoma [J]. , 2017, 37(5): 462-465.
[10]	. The expressions of Slug and E-cadherin in oral squamous cell carcinoma [J]. , 2017, 37(3): 214-218.
[11]	. The prognostic significance of peripheral blood eosinophilia in oral squamous cell carcinoma after surgery [J]. , 2016, 36(6): 546-549.
[12]	. MicroRNA27b inhibits cell proliferation of oral squamous cell carcinoma through targeting FZD7 [J]. , 2016, 36(3): 200-205.
[13]	. A primary study of differentially expressed proteins in the serums of healthy people and patients with oral squamous cell carcinoma [J]. , 2016, 36(2): 105-108.
[14]	. The possible role of miRNA in Oral squamous cell carcinoma [J]. , 2016, 36(10): 957-960.
[15]	. Expression of CD105 and its correlations with pathologic characteristics and prognosis in oral squamous cell carcinoma [J]. , 2015, 35(4): 266-269.