基质金属蛋白酶-3在舍格伦综合征患者唾液和唇腺中的表达

Abstract

Abstract: [Abstract]Objective: To investigate the expression of matrix metalloproteinase 3 (MMP-3) in the labial glands and saliva of patients with Sjogren's syndrome and to determine whether its expression level is correlated with pathological grade. Method: The glandular glands and saliva of 35 patients with Sjogren's syndrome (experimental group) and 20 patients with mucinous gland cysts (control group) are collected. The enzyme-linked immunosorbent assay (ELISA) is used to detect the expression level of MMP-3 in the saliva of the two groups. Using immunohistochemical method to observe the expression of MMP - 3 in labial gland.The intensity of MMP-3 expression in the labial glands is quantified by using image analysis software (IPP 6.0). The pathological grade is divided into two groups of grade 1, grade 2 and grade 3 and grade 4. Results: The expression of mmp-3 in saliva and labial glands of the experimental group is higher than that of the control group, and the difference is statistically significant (p<0.05). The expression level of MMP-3 in the saliva and labial glands of patients with high pathological grade is higher than that of pathology. Patients with low grades has statistically significant difference (p<0.05). Conclusion: MMP-3 in the labial glands of patients with Sjorgen’s syndrome may be involved in the destruction of acinar and glandular stroma, leading to the occurrence of disease. The expression level of MMP-3 in saliva and labial glands may be an indicator of Sjorgen’s syndrome and provide a reference for clinical diagnosis and treatment.

Key words: Key words：Sjorgen syndrome Salivary Labial Gland Tissue pathological grade MMP-3

CLC Number:

R781.5

References 20

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Expression of matrix metalloproteinase-3 in salivary and labial gland tissue in patients with Sj?rgen syndrome

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