小分子化合物在骨缺损修复中对成骨分化的调控

Abstract

Abstract: Bone loss is always a quite difficult problem in prosthodontics and oral implantology. A special group of small osteoinductive molecules was found to guide osteogenic differentiation, promote bone formation and mineralization. Owing to their small sizes that are capable of regulating cell functions, higher stability and non-immunogenicity, small osteoinductive molecules have gained lots of attention. Phenamil, statins, Purmorphamine, cAMP analogues, Oxysterols and Melatonin are proved to have ability to control osteogenesis through various osteogenic signaling pathways and increase the osteogenic gene expression. This review is going to show the types, functions and the functional mechanisms of these small osteoinductive molecules.

Key words: Small Molecules, Osteogenesis, Bone Regeneration, Mmesenchymal Stem Cells

CLC Number:

References 45

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Osteogenic effects of small molecules on bone defect repair

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