B10细胞与牙周炎免疫调控的研究进展

›› 2019, Vol. 39 ›› Issue (8): 748-752.

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Research progress of B cell in periodontitis immunomodulation

Received:2018-10-29 Revised:2018-11-26 Online:2019-08-28 Published:2019-08-23

Abstract

Abstract: B10 cell（IL-10 producing B cell）exerts significant immunomodulatory effects through the production of interleukin (IL)-10 and the expression of CD1d, CD80, CD86, FasL. It plays an important immunomodulatory role in autoimmune diseases and infection disease. Recent studies show that local induction of the expression of B10 cell and adoptive transfer of B10 cell can alleviate inflammation of periodontal tissue and alveolar bone resorption. Thus, the research on the function of B10 cell in periodontitis will be of great help for the further study on the therapy of periodontal diseases.

Key words: B10 cell, periodontitis, immune tolerance

CLC Number:

R781.4

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Research progress of B cell in periodontitis immunomodulation

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