阿奇霉素对牙周炎大鼠牙槽骨影响的Micro-CT研究

Abstract

Abstract: Objective To study the effects of azithromycin on the micro structure of alveolar bone of rats with periodontitis by MicroCT. Methods Male SD rats were randomly divided into 3 groups:control group, ligation group, azithromycin group. The left maxillary first molars of rats in ligation group and the azithromycin group were ligated by thread to establish the experimental periodontitis model. From the ligation, rats in azithromycin group received intraperitoneal injection of azithromycin 3.5 mg/kg. After two weeks’ injection, the rats were killed and the maxillary bones were removed. By MicroCT the changes of maxillary first molar alveolar bone loss and microstructure were analyzed. Results Compared with the control group, the height of the maxillary first molar surrounding alveolar bone in ligation group decreased obviously, while in drug induced state, alveolar bone resorption of azithromycin group decreased significantly. Azithromycin inhibited the alveolar bone height decrease. After ligation, micro structure of rats’ alveolar bone obviously changed. The values of BV /TV, Tb.N, Tb.Th and BMD significantly decreased, while that of Tb.Sp increased. And the alveolar bone microstructure parameters of azithromycin group could reach a certain level of recovery, and the difference with the control group decreased significantly. Conclusion Azithromycin can prevent alveolar bone of experimental periodontitis rats from continuing to be destroyed, which has a therapeutic effect on experimental periodontitis rats. Key words: azithromycin; experimental periodontitis; alveolar bone; MicroCT； SD rats

Key words: azithromycin, experimental periodontitis, alveolar bone, Micro-CT, SD rats

CLC Number:

R780.2

References 17

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Micro-CT study on the effect of azithromycin on alveolar bone in rats with periodontitis

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