Abstract: In the treatment of dental caries, the remineralization of dental hard tissue and the bonding of restorative materials and dental hard tissue in the complex oral environment have been the key issues in the field of dental treatment. The regulation of extracellular matrix proteins and their derivatives or synthetic polymers on the development of tooth hard tissues during the development of natural enamel and dentin. Mussels in the ocean have mussel foot silk protein to provide strong adhesion to rocks. These natural biomimetic biomolecular materials are related to the remineralization of tooth hard tissue and the bonding between restoration materials and tooth hard tissue in the complex oral environment. The purpose of this paper is to summarize the remineralization of these biomimetic biomaterials in the hard tissues of teeth and the bonding effect between the restorative materials and the hard tissues of teeth in recent years.

Key words: biomimetic remineralization, amelogenin, collagenous proteins , hydroxylapatite, mussel foot proteins