Piezo1离子通道在口腔医学中的研究进展

Abstract

Abstract: Mechanosensitive channel is an ion channel that can sense changes in the cell membrane's mechanical forces and respond quickly. This reaction can convert the mechanical signals felt by the cell membrane into electrical or chemical signals, which affects the body's physiology and biochemistry. Costo and other scientists discovered the Piezo channel protein as a type of mechanically sensitive membrane ion channel that is widely found in animals and plants and eukaryotes in 2010. It contains two proteins in vertebrates, namely Piezo1 (Fam38A) and Piezo2 ( Fam38B). In humans, Piezo1 is mainly expressed in fluid pressure and flowing non-sensory tissues (eg, kidneys, red blood cells), while Piezo2 is mainly expressed in sensory tissues (eg, dorsal root ganglion (DGR) and Merkel cells). This article reviews the research status of Piezo1 mechanically sensitive ion channels and their research in the field of stomatology.

Key words: 　Piezo1, Mechanosensitive ion channels, Pain, Bone remodeling, Periodontal tissue

CLC Number:

Ｒ780．1

References 37

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Research progress of Piezo1 ion channel in stomatology

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