›› 2020, Vol. 40 ›› Issue (11): 1050-1053.

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Research progress on CPNE7 in oral tissue regeneration

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  • Received:2020-03-03 Revised:2020-05-19 Online:2020-11-28 Published:2020-11-24

Abstract: In recent years, with the development of tissue engineering, calcium phospholipid-binding protein VII (Copine VII, CPNE7), as a member of the Copine family, has been found to play more roles in oral tissue regeneration besides its roles in the occurrence and development of cancers. In addition to inducing the difference of odontogenic/non-odontogenic cells into odontoblasts and promoting the differentiation of odontoblasts into dentin, CPNE7 can also promote periodontal tissue regeneration and osteogenesis. In this review, the effects of CPNE7 on oral tissue regeneration and development of neoplastic diseases are presented which will provide a reference for researches in tissue regeneration and diagnosis and treatment of related diseases.

Key words: CPNE7, dentin regeneration, periodontal regeneration, bone regeneration, neoplastic diseases

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