牙源性干细胞来源的外泌体的研究进展

Abstract

Abstract: As micro vesicles secreted by cells, exosomes, containing cholesterol, protein and nucleic acid, play an important role in cell communication, tissue damage repair and regeneration. MSCsderived exosomes not only retain the function of MSCs, but also avoid the limitations, risks and ethical issues related to cell transplantation. They may become an effective means of "cellfree therapy", and have broad prospects for medical application. This article summarizes the origin and characteristics of exosomes and their role in tissue damage repair, and focuses on progress of research on exosomes from dental tissuederived stem cells in promoting blood vessel regeneration, immune regulation, and in promoting odontogenic differentiation, bone tissue damage repair, and therapy for neurodegenerative diseases, providing new research strategies for clinical treatment.

Key words: dental tissue-derived stem cells, exosomes, angiogenesis, immune regulation, odontogenic differentiation

CLC Number:

R329.28

References 48

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Progress of research on exosomes from dental tissue-derived stem cells

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