Abstract: Exosomes are natural nanovesicles with a diameter of 40 to 100 nm that can be secreted and taken up by a variety of cells. They carry the endogenous genetic information of the mother cell. As a paracellular secretion pathway, it also plays an important role in plasma membrane exchange and transporting proteins, mRNA and other lifeactive substances, so it can play an important regulatory role in various physiological and pathological processes. In terms of oral tissue regeneration, exosomes can not only trigger pulplike tissue regeneration, but also play a prominent role in periodontal tissue regeneration, angiogenesis, bone regeneration, and neural tissue repair. This article elaborates the research progress of the origin, biological traits, functions, and the application of exosomes in oral tissue repair and regeneration, providing reference basis for further research.

Key words: mesenchymal stem cells, exosomes, immunity, tumor, tissue repair and regeneration