Abstract: Objective　 To observe the clinical application of computer aided design and computer aided manufacturing (CAD/CAM) in the functional reconstruction of mandible defects with fibular musculocutaneous flap transplantation. Methods The data of 9 patients with mandibular segmental defect resulting from mandibular lesion were analyzed. (CAD/CAM) technology was used to design fibula shaping to create favorable bone conditions for dental implant repair. The surgical guide plate was made by rapid prototyping. The titanium plate was reconstructed by preforming on the reconstructed solid model. Among them, 5 patients completed the implantation and restoration one year after surgery. The patients' facial shape, mouth width/type, temporomandibular joint, occlusal function, peri-implant soft tissue and bone tissue were followed up and observed. Bone level at the edge of the implant was measured 6 to 12 months after the restoration. Result All the flaps survived in 9 cases. Under the guidance of the surgical guide plate, the osteotomy and fibula were shaped smoothly and the time consumption was reduced. The 5 patients who completed the implantation and restoration were followed up at 6 and 12 months after the implantation. The patients showed full lateral shape, bilateral symmetry, and mouth width of 3.1-3.9mm. The soft tissue color around the implant was normal without obvious gingivitis around the implant. The occlusal relationship and masticatory function were normal. CBCT showed that there was no obvious absorption of bone tissue around the implant.Conclusion CAD/CAM can guide the shaping of fibula more accurately and create favorable bone conditions for the reconstruction of dental defects.

Key words: computer aided design and computer aided manufacturing (CAD/CAM), Single fibula muscle flap, implant restoration, Cone-beam computer tomography, Bone level at the edge of implant