Abstract: It is commonly believed that pulp tissue is unable to regenerate once infection and necrosis take place. Now with the development of science and technology, dental pulp revascularization has brought new possibilities for pulp regeneration of immature permanent teeth. And stem cells, growth factors, and scaffolds all play critical roles in the process, especially scaffold materials, have got more and more attention recently. The scaffolds can be mainly divided into natural and synthetic materials. Though they have different characteristics, they all share the functions of acting as supports for three-dimensional structure and providing favorable environment for adhesion, proliferation, and differentiation of stem cells. At present, the scaffolds applied in clinics are mostly natural materials, especially induced bleeding, venous blood, and platelet derivatives. Whereas synthetic materials are still at the research stage, they attract people’s attention by their characteristics of innocuity, good biodegradation, and controllability. This review summarizes the research progress on the classification, features, advantages, and disadvantages of various scaffold materials in the dental pulp revascularization.

Key words: regenerative endodontics treatment, scaffold, tissue engineering