牙周炎与慢性阻塞性肺疾病相关性的研究进展

Abstract

Abstract: The relationship between periodontitis and systemic diseases has become a research hotspot, and the correlation between periodontitis and chronic obstructive pulmonary disease has been paid more and more attention. More epidemiological investigations have confirmed that periodontitis affects the lung function of patients and promotes the aggravation of symptoms of chronic obstructive pulmonary disease. Therefore, periodontal intervention can reduce periodontal symptoms, so as to reduce the symptoms of patients with chronic obstructive pulmonary disease. In this paper, we further reviewed the mechanism of the relationship between them: periodontitis can aggravate lung injury by inducing systemic immune response; local periodontal pathogens alone or cooperatively induce the elevation of the level of pulmonary inflammatory cytokines and the accumulation of immune cells promoting the injury of lung epithelial cells.

Key words: Periodontitis, Chronic obstructive pulmonary disease, Porphyromonas gingivalis, Pulmonary function

References 39

[1]	Kassebaum N J, Bernabé, E, Dahiya M, et al.Global Burden of Severe Periodontitis in 1990-2010: A Systematic Review and Meta-regression[J].J Dent Res, 2014, 93(11):1045-1053
[2]	Tonetti Maurizio S, Van Dyke, Thomas E.Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFPAAP Workshop on Periodontitis and Systemic Diseases[J].J Clin Periodontol, 2013, 40(s14):S24-S29
[3]	Vitkov Ljubomir, Hannig Matthias, Minnich Bernd et al.Periodontal sources of citrullinated antigens and TLR agonists related to RA[J].Autoimmunity, 2018, 51(6):304-309
[4]	Sparks Stein Pamela, Steffen Michelle J, Smith Charles et al.Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease [J].Alzheimers Dement, 2012, 8(3):196-203
[5]	Diaz-Guzman E, Mannino DM.Epidemiology and Prevalence of Chronic Obstructive Pulmonary Disease[J].Clin Chest Med, 2014, 35(1):7-16
[6]	Scannapieco F A, Papandonatos G D, Dunford R G.Associations Between Oral Conditions and Respiratory Disease in a National Sample Survey Population[J].Ann Periodontol, 1998, 3(1):251-256
[7]	Scannapieco F A, Ho A W.Potential Associations Between Chronic Respiratory Disease and Periodontal Disease: Analysis of National Health and Nutrition Examination Survey III[J].J Periodontol, 2001, 72(1):50-56
[8]	Si Y, Fan H, Song Y, et al.Association Between Periodontitis and Chronic Obstructive Pulmonary Disease in a Chinese Population[J].J Periodontol, 2012, 83(10):1288-1296
[9]	Peter K P, Mute B R, Doiphode S S, et al.Association Between Periodontal Disease and Chronic Obstructive Pulmonary Disease: A Reality or Just a Dogma?[J].J Periodontol, 2013, 84(12):1717-1723
[10]	Zhou Xuan, Wang Zuomin, Song Yiqing et al.Periodontal health and quality of life in patients with chronic obstructive pulmonary disease[J].Respir Med, 2011, 105(1):67-73
[11]	Chung J H, Hee‐Jin Hwang, Sun‐Hyun Kim, et al.Associations Between Periodontitis and Chronic Obstructive Pulmonary Disease: The 2010 to 2012 Korean National Health and Nutrition Examination Survey[J].J Periodontol, 2016, 87(8):864-871
[12]	Terashima Takeshi, Chubachi Shotaro, Matsuzaki Tatsu et al.The association between dental health and nutritional status in chronic obstructive pulmonary disease[J].Chronic Respiratory Disease, 2017, 14(4):334-341
[13]	Winning Lewis, Patterson Christopher C, Cullen Kathy M et al.Chronic periodontitis and reduced respiratory function[J].J Clin Periodontol, 2019, 46(3):266-275
[14]	Takeuchi K, Matsumoto K, Furuta M et al.Periodontitis Is Associated with Chronic Obstructive Pulmonary Disease[J].J Dent Res, 2019, 98(5):534-540
[15]	Hobbins Stephanie, Chapple Iain Lc, Sapey Elizabeth et al.Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors?[J].Int J Chron Obstruct Pulmon Dis, 2017, 12(-):1339-1349
[16]	Kucukcoskun Meric, Baser Ulku, Oztekin Gorkem et al.Initial periodontal treatment for prevention of chronic obstructive pulmonary disease exacerbations [J][J].J Periodontol, 2013, 84(7):863-870
[17]	Zhou Xuan, Han Jing, Liu Zhiqiang et al.Effects of periodontal treatment on lung function and exacerbation frequency in patients with chronic obstructive pulmonary disease and chronic periodontitis: a 2-year pilot randomized controlled trial[J].J Clin Periodontol, 2014, 41(6):564-572
[18]	Usher Adam K H, Stockley Robert A .The link between chronic periodontitis and COPD: a common role for the neutrophil?[J].BMC Med, 2013, 11(-):241--
[19]	Zhou Xuan, Han Jing, Song Yiqing et al.Serum levels of 25-hydroxyvitamin D,oral health and chronic obstructive pulmonary disease[J].J Clin Periodontol, 2012, 39(4):350-356
[20]	赵倩, 王左敏, 李威, 等.牙周炎和慢性阻塞性肺疾病对血清白细胞介素17表达的影响[J].牙体牙髓牙周病学杂志, 2010, 20(4):183-186
[21]	王悦颖, 林梅, 王蕾, 等.慢性牙周炎和慢性牙周炎合并慢性阻塞性肺疾病患者血清中-IL-2、IL-4、IL-6、IL-10、IFN-γ及TNF-α 的检测及临床意义[J].中国医师杂志, 2017, 19(8):1148-1151
[22]	林梅, 张冬雪, 王左敏.牙周炎对慢性阻塞性肺疾病大鼠肺损伤的作用研究[J].实用口腔医学杂志, 2012, 28(5):545-549
[23]	Almeida-da-Silva Cássio Luiz Coutinho, Alpagot Tamer, Zhu Ye et al.Chlamydia pneumoniae is present in the dental plaque of periodontitis patients and stimulates an inflammatory response in gingival epithelial cells[J].Microb Cell, 2019, 6(4):197-208
[24]	Lopes Mabel P, Cruz álvaro A, Xavier Márcia T et al.Prevotella intermedia and periodontitis are associated with severe asthma[J].J Periodontol, 2019, -(-):1-9
[25]	Porto A N, Cortelli S C, Borges A H et al.Oral and endotracheal tubes colonization by periodontal bacteria: a case-control ICU study[J].Eur J Clin Microbiol Infect Dis, 2016, 35(3):343-351
[26]	Card Jeffrey W, Carey Michelle A, Voltz James W et al.Modulation of allergic airway inflammation by the oral pathogen Porphyromonas gingivalis[J].Infect Immun, 2010, 78(6):2488-2496
[27]	Tan Lisi, Tang Xiaolin, Pan Chunling et al.Relationship among clinical periodontal,microbiologic parameters and lung function in participants with chronic obstructive pulmonary disease[J].J Periodontol, 2019, 90(2):134-140
[28]	Tan Lisi, Tang Xiaolin, Pan Chunling et al.Relationship among clinical periodontal,microbiologic parameters and lung function in participants with chronic obstructive pulmonary disease[J][J].J Periodontol, 2019, 90(2):134-140
[29]	谭丽思, 潘春玲, 王宏岩, 等.COPD患者口腔和呼吸道内牙龈卟啉单胞菌、齿垢密螺旋体和福赛坦菌的同源性分析[J].中国微生态学杂志, 2015, 27(5):534-538
[30]	Hayata Mayumi, Watanabe Norihisa, Tamura Muneaki et al.The Periodontopathic Bacterium Fusobacterium nucleatum Induced Proinflammatory Cytokine Production by Human Respiratory Epithelial Cell Lines and in the Lower Respiratory Organs in Mice[J].Cell Physiol Biochem, 2019, 53(1):49-61
[31]	Scannapieco FA, Wang B, Shiau HJ.Oral bacteria and respiratory infection: effects on respiratory pathogen adhesion and epithelial cell proinflammatory cytokine production[J].Ann Periodontol, 2001, 6(1):78-86
[32]	Petelin Milan, Naruishi Koji, Shiomi Nobuyuki et al.Systemic up-regulation of sTNFR2 and IL-6 in Porphyromonas gingivalis pneumonia in mice[J].Exp Mol Pathol, 2004, 76(1):76-81
[33]	Benedyk Ma?gorzata, Mydel Piotr Mateusz, Delaleu Nicolas et al.Gingipains: Critical Factors in the Development of Aspiration Pneumonia Caused by Porphyromonas gingivalis[J].J Innate Immun, 2016, 8(2):185-198
[34]	Li Qian, Pan Chunling, Teng Di et al.Porphyromonas gingivalis modulates Pseudomonas aeruginosa-induced apoptosis of respiratory epithelial cells through the STAT3 signaling pathway[J].Microbes Infect, 2014, 16(1):17-27
[35]	Chen Yongju, Zhou Rui, Yi Zhe et al.Porphyromonas gingivalis induced inflammatory responses and promoted apoptosis in lung epithelial cells infected with H1N1 via the Bcl-2BaxCaspase-3 signaling pathway[J].Mol Med Rep, 2018, 18(1):97-104
[36]	Li Xin, Li Chen, Liu Jun-Chao et al.In vitro effect of Porphyromonas gingivalis combined with influenza A virus on respiratory epithelial cells[J].Arch Oral Biol, 2018, 95(-):125-133
[37]	Parashar Pranav, Parashar Ankita, Saraswat Nidhi et al.Relationship between Respiratory and Periodontal Health in Adults: A Case-Control Study[J].J Int Soc Prev Community Dent, 2018, 8(6):560-564
[38]	Bostanci Nagihan, Thurnheer Thomas, Aduse-Opoku Joseph et al.Porphyromonas gingivalis regulates TREM-1 in human polymorphonuclear neutrophils via its gingipains[J].PLoS ONE, 2013, 8(10):e75784--
[39]	Zhang Liping, Gao Li, Xu Chenrong et al.Porphyromonas gingivalis lipopolysaccharide promotes T- helper 17 cell differentiation from human CD4 naive T cells via toll-like receptor-2 in vitro[J].Arch Oral Bio, 2019, 107(-):104483--

Research progress of correlation between periodontitis and chronic obstructive pulmonary disease

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