KLFs与肿瘤干细胞相关性的研究进展

Abstract

Abstract: Malignant tumor is one of the major diseases affecting human survival currently. Surgery and chemoradiotherapy are still the most widely used conventional treatment methods at present, but the tumor metastasis and recurrence are still common in decades. Looking for a new effective treatment method is a problem to be solved. Cancer stem cells are a few subsets of cells in tumor with unlimited self-renewal and differentiation potency, and Kruppel-like transcription factors play important roles in maintaining stemness and obtaining invasion ability of cancer stem cells. In recent years, the gradual improvement of cancer stem cell theory and the study of molecular mechanism have provided not only a new direction for the study of the pathogenesis, metastasis and recurrence mechanism of malignant tumors, but also a new entry point for the treatment of malignant tumors. This article reviews the possible relationship between KLFs and cancer stem cells.

Key words: cancer stem cells, cancer, KLF-4, KLF-7, KLF-8

CLC Number:

R7630.231

References 55

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Research progress of the correlation between KLFs and cancer stem cells

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