Abstract: Objective　To investigate the effect of gender on the evaluation of soft tissue profile in patients with skeletal Class Ⅲ malocclusion, and to provide reference for orthodontic clinic. Methods　The silhouette data of 30 orthodontic patients(15 male and 15 female respectively) were collected before treatment. Photoshop software was used to conceal their hair and neck which exposed gender features.54 junior undergraduate students(27 male and 27 female respectively) were selected to score the processed images on a numerical rating scale(NRS), and then a complete silhouette score was assigned 40 minutes later. The order was adjusted randomly.SPSS 17.0 software was used for data statistical analysis. Results　There was no significant difference between the silhouette score without gender characteristics and the silhouette score with gender characteristics in female and male patients(P>0.05). Conclusion　Gender of patients with skeletal Class Ⅲ malocclusion has no significant effect on the evaluation of soft tissue profile.It is suggested that in the process of orthodontic design and treatment, attention should be paid to the aesthetic analysis of the profile and the postoperative improvement rather than gender difference.

Key words: Facial profile, Aesthetic evaluation, Skeletal class Ⅲ malocclusion, Gender