Prx1+骨骼干细胞的研究进展

Abstract

Abstract: The paired related homeobox gene Prx1 is highly expressed during embryonic lib formation and craniofacial development. Postnatal Prx1+cells located in periosteum, bone marrow or calvarial sutures display the characteristics of mesenchymal stem cells(MSCs) or skeletal stem cells(SSCs). Recent research has shown that Prx1+SSCs participate in fracture healing and respond to mechanical forces in bone. At the same time, Prx1+cells in the periodontal ligament are noticed for its contribution to the normal development and defect repair of periodontal tissues. This paper reviews the characteristics and function of Prx1 gene and Prx1+cells and gives a summary of the role Prx1+SSCs play in bone remodeling and repair, which is helpful for the further studies of SSCs in regulating orchestrate craniofacial growth and promoting the regeneration of alveolar bones.

Key words: skeletal stem cells, Prx1, craniofacial, bone remodeling, mechanical force

CLC Number:

R349.6

References

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Research progress of rx1+ skeletal stem cells

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