Abstract: Recurrent aphthous ulcer (RAU) is a common oral mucosal inflammatory ulcer disease, which has the characteristics of recurrence, periodicity and self-limitation. The investigation found that RAU has a higher incidence in the population and ulcer attacks The burning pain is obvious, especially when the major recurrent aphthous ulcer attacks, the pain is severe, which seriously affects people's daily work and life. The etiology and pathogenesis of RAU are still unknown, and the influence of psychological factors on RAU cannot be ignored. Up to now, domestic and foreign researches on psychological factors of RAU tend to focus on the evaluation of subjective scale, and there are few studies on its objective biomarkers.In this paper, we review the recent advances in the study of biomarkers of RAU psychological factors at home and abroad.

Key words: Recurrent aphthous ulcer, Psychological factors, Biomarkers, Research progress