Abstract: Objective To observe and study the clinical effect of Pingyangmycin injection under robot assisted localization in the treatment of vascular malformations in oral and maxillofacial region. Methods A total of 20 patients with vascular malformations in oral, maxillofacial and cervical region who had complete clinical data in our hospital from 2017 to 2021 were collected and analyzed retrospectively. All patients were treated with Pingyangmycin injection assisted by robot localization. The prognosis of patients was observed and recorded. The changes of tumor size were evaluated by maxillofacial enhanced CT or MRI as the evaluation index of curative effect. Results All the 20 patients successfully completed the operation with the assistance of robot. The clinical effective rate was 95%, and there was no adverse drug reaction after the operation. This technique has good safety, gives full play to the advantages of accurate robot positioning, enhances the interaction area between drugs and vascular malformation endothelial cells by using the method of needle withdrawal administration, gives full play to the role of drug therapy, and shortens the interval time of Pingyangmycin drug injection. Conclusion Robot assisted localization and Pingyangmycin drug injection in the treatment of vascular malformation is safe and effective, with small trauma and high precision, which can accept repeatable injection treatment and achieve the maximum preservation of the original organ shape and function, and has high clinical application value.

Key words: Robot, Pingyangmycin, oral and maxillofacial, vascular malformation, robot assisted localization