Abstract: Titanium implant is widely used in dental restorations due to its good biocompatibility. It is known to all that implant surface morphology and physicochemical properties have positive effects on the integration of hard and soft tissues which surround implant, and the relevant physicochemical properties will change with surface morphology changing. Through the preparation of bionic nanostructures to perform implant surface modification, peri-implant connective tissue adhesion can be improved, and a specific fiber direction can be formed and so on, which is one of the ways to extend the longevity of implant. In this paper, the effects of titanium surface nanostructures on the fibroblasts biological behavior are reviewed, and the physicochemical characteristics with the change of surface morphology are briefly introduced.

Key words: surface topography, nanostructure, fibroblasts, connective tissue, oral implant